AlfaTech Big Book - Life Sciences

INNOVATIVE IDEAS | INTEGRATED SOLUTIONS | SUSTAINABLE PARTNERS

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OVERVIEW / Profile & Services

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Sustainability

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Markets & Relevant Projects

11.8.19

Profile & Services OVERVIEW 01

P ROF I L E

AlfaTech has built its reputation on providing the most innovative and sustainable engineering solutions from master planning through construction administration. Our presence is not only California and Atlanta, but also internationally. Our clients include numerous large multi-national firms, many ongoing clients we’ve been serving for years. We strive to provide intelligent and innovative strategies starting with project inception, in order to provide maximum benefit to our clients during the entire development process whether it be new high-rise projects, mixed use projects or revitalization of existing communities. Our team provides the most appropriate engineering design solutions which are highly efficient and cost effective, and promotes the greatest possible return on investment for our clients. Our goal is to build the most dynamic relationships, be attentive to the needs of our clients and partners, and be true team players. With this mindset, we’ve built a stellar list of clients.

Uber, Mission Bay 1 & 2

Eventbrite

eBay

UNITED STATES San Francisco San Jose Los Angeles Atlanta

INTERNATIONAL Europe Asia Middle East Latin America Africa

Additional Resources Through Our Sister Companies

65+ locations | 30 countries | 4,000+ staff

S E R V I C E S

MECHANICAL ENGINEERING DESIGN HVAC

ARCHITECTURAL LIGHTING DESIGN Lighting and Lighting Controls Lighting Calculations

COMMISSIONING | ENERGY SOLUTIONS Early Quantifiable Energy Study Incentives Energy Star® Assessments Retro-commissioning (RCx) Monitoring Brand Continuous Commissioning (MBCCx) ASHRAE Level 1, 2 and 3 Energy Audits Measurement and Verification (M&V) of installed projects Energy Modeling Net Zero Energy Budgeting HVAC/Chilled Water Plant Optimization

Heating Systems Water and Gas Cooling Systems / Chilled Water Dehumidification Systems Contamination Sensitive Areas Industrial Hygiene Systems Low Tolerance Temp Control Title 24 Analysis and Design Heat Recovery Systems Central Utility Plants Air Handlers HVAC System Controls PLC Programming Fire Protection and Plumbing

Customized ROI Calculations Sustainable Lighting Design

Energy Savings Analysis Custom Lighting Fixtures Design for finishes, fabrics and light sources

TECHNOLOGY DESIGN Low Voltage Design Security Design Audio Visual Design Wireless Design & Modeling

PROCESS Industrial Waste Collection Acid Neutralization Bio-Kill Waste System Process Waste Containment Ultra pure De-ionized Water Systems

Strategic Consulting Project Management Relocation & Migration

ELECTRICAL ENGINEERING DESIGN Power Systems

Emergency & Standby Power Lighting and Lighting Controls Security Systems 24 / 7 Power Systems (UPS) Power Monitoring Systems Toxic Gas Monitoring Graphic Control and Alarm Panels Grounding and Bonding

USP Water WFI Water Specialty Chemicals Chemical Storage

SUSTAINABILITY Sustainability Planning (Organizational and Infrastructural) LEED / Green Building Consulting Masterplanning Life Cycle Cost Assessment Occupant Wellness and Comfort

Lab and Special Gas Systems Ultra High Purity Gas Piping

Bulk & Specialty Gases Toxic Materials Handling Code Compliance Process Distribution Piping Process Cooling Water Medical Gas Medical Vacuum Waste Anesthetic Gas Disposal system (WAGD)

Energy Management Energy Conservation Fire Alarm Systems Public Address Systems Plug Loads Control

Façade Engineering CFD / Wind Studies Wind Studies Thermal Stratification Studies Energy Concept Studies

Dental Vacuum System Dental Water System

S E R V I C E S

GREEN BUILDING

SUSTAINABILITY

LIFE

MECHANICAL ENGINEERING DESIGN

OF A BUILDING RETRO COMMISSIONING

ELECTRICAL ENGINEERING DESIGN

ARCHITECTURAL LIGHTING

TECHNOLOGY

COMMISSIONING / ENERGY SOLUTIONS

CONSTRUCT I ON

OCCUPANCY

END OF USE

DE S I GN

C L I EN T S

JDS Uniphase Corporation John Muir Medical Center Johnson & Johnson Johnson Controls JP Morgan Chase JRH Biosciences Juniper Networks Junipero Serra High School Kaiser HealthConnect Kaiser Permanente Kasowitz, Benson, et al

Novell Novellus Systems NVIDIA Ohlone Community College OptiSolar Oracle Orchard Properties Oread Pacific Bell PDL BioPharma PG&E Panattoni Europe Pfizer Philips Semiconductor Pitney Bowes Polycom Port of San Francisco Presidio Trust Price Waterhouse Coopers Qualcomm Queens Medical Center Rambus Raytheon Company

Scripps Memorial Hospital Sequoia Hospital CHW Sequoia UHSD Siemens SLAC National Accelerator Laboratory Solectron Corporation Sony America Spansion Sprint SRI International (Stanford Research) Stanford Healthcare & Clinics Stanford University Stanford University Medical Center

365 Main 3M Company AARP Abbott Biotherapeutics Abbott Laboratories Abbvie Abgenix Abt Associates ACCO Engineered Systems Adaptec AOC Adobe Systems Advanced Micro Devices Advantest America Advent Software Aetna Affymetrix Agilent Technologies Agnes Medical Center Akamai Technologies Alcoa Allen, Matkins, et al Alliance Bernstein, LLP Alta Bates Health System Altera Corporation Alum Rock School District Alza Amazon/Lab 126 Ambiance Associates Ambience Interiors Amdocs American Express Company Amgen Amprius

Bingham McCutchen, LLP Bio-Rad Laboratories BioGenex Biomarin Pharmaceutical BioMed Realty Trust Bloom Energy BMC Software Booz Allen Hamilton Inc

County of Sacramento County of San Mateo County of Santa Clara Credence CSAA

CSU Northridge Cupertino USD Daughters of Charity Health Dell Deloitte Consulting Digital Realty Trust Dignity Health Dominican Hospital Dropbox Dupont East Side Union HSD eBay Eil Lilly & Company Elsevier Inc Emirates National Oil Empire State Development Equinix Equis Corporation Ericsson Ernst & Young LLP Exelixis Ferrari Maserati of Silicon Valley Fidelity Investments Fireman’s Fund Insurance First Franklin Financial Corp Flextronics Foundry Networks Franklin Templeton Investments Genencor Genentech General Dynamics General Electric Genzyme Corporation Gilead Sciences Goldman Sachs Good Samaritan Hospital GSA Harbor UCLA Medical Center Hayward USD

Boston Properties Boston Scientific Bradford Schools Bristol-Myers Squibb Broadcom Broadreach Capital Partners Brocade Buck Institute Stem Cell Research Lab Cadence Design Systems Cal Pacific Med Center California Department of Mental Health CarrAmerica Development Cedars-Sinai Medical Center Chabot Las Positas CCD Charles Schwab Chevron Children’s Hospital, Los Angeles County Children’s Hospital, Oakland Children’s Hospital, Orange County Children’s Hospital, San Antonio Chinese Hospital Cisco Systems Citigroup Realty Services

Kimpton Hotels KLA-Tencor Corp La Clinica De La Raza

Stion Corporation Stryker Endoscopy Stubhub Sun Microsystems SunPower Sutter Health

Lam Research Laney College

Lawrence Berkeley Lab Letterman Digital Arts Levi Strauss & Company Linear Technology LinkedIn Lockheed Martin Corp Logitech Longs Drug Stores Los Gatos Saratoga HSD Lumentum Marriott International Martin Luther King, Jr. Community Hospital Marvell Semiconductor Maxim McKesson Medarex Menlo Park City School District Mercy Southwest Hospital Microsoft

Sybase Inc Symantec Synopsys Inc Sysorex T-Mobile Tencent Tesla Motors The Gap Twitter Uber UC Berkeley UC Davis UC Davis Medical Center UC San Francisco University of Nevada University of Virginia URS Valley Medical Center Verisign Verity Health Verizon Communications Veteran’s Administration Visa International Vivus VMware Wachovia Bank Washington Hospital Xoma Therapeutics Yahoo

Regional Medical Center Riverbed Technologies Robert Half International Roche Bioscience Ross Stores Sacramento Municipal Utility District Safeway Saint Francis Memorial Hospital Saint Joseph Hospital Saint Louise Regional Hospital Saint Mary’s Hospital Samaritan Medical Center Samsung San Francisco City Hall San Francisco International Airport San Francisco USD San Jose Medical Center San Jose Redevelopment Agency San Jose State University San Jose USD San Mateo CCCD San Mateo County Office of Education Sandia Laboratories Santa Clara County Health Dept. Santa Clara County Library Santa Clara County Office of Education Santa Clara USD Santa Clara University

City of Cupertino City of Foster City City of Fremont City of Monterey City of Mountain View City of Newark City of Oakland City of Palo Alto City of Sacramento City of San Jose City of San Mateo City of Santa Clara City of Saratoga City of South San Francisco City of Sunnyvale College of Contra Costa College of Marin Colliers International Computer Associates Int’l Compuware CoreSite County of Monterey

UC Santa Cruz UC Los Angeles UCLA Outpatient Surgery/Oncology Center UCSF Mission Bay Medical Center Ultratech University of Colorado Hospital

Amstein + Walthert Anderson Architects Anixter Applied Dynamics Applied Materials Aradigm AT&T Park Clinic Atmel Corp Autodesk Avaya Avid Technology Avidex BAE Systems Bank of America Banuazizi Architects Bayer Healthcare Bechtel Corporation Bell, Rosenberg, et al Berryessa USD

Mills/Peninsula Hospital Mission Oaks Hospital Molecular Devices Monterey Peninsula College Morgan Hill USD Morgan Stanley Morrison & Foerster Motorola Mountain View School District MW Zander NASA-Ames National Semiconductor Network Appliance Nokia Nortel Networks North Bay Medical Center Northrop Grumman Novartis

Hewlett Packard Highland Hospital Hitachi America IBM Impax Laboratories Informatica Corporation Intel InterMune Intuit J&W Scientific

SAP Labs LLC Saratoga USD Savvis

SUSTAINABILITY 02

S U S T A I NA B I L I T Y

At AlfaTech, we have a multidisciplinary team of experts to assess and design projects with a holistic approach. Working alongside owners, architects and other stakeholders, we examine every project in a comprehensive, systematic way to meet the client’s sustainability, energy, water and environmental quality goals. AlfaTech goes beyond engineering – our suite of energy, water and sustainability assessment services creates projects that benefit the bottom line. We provide expert studies in all qualitative aspects of the built environment such as day lighting, thermal comfort, advanced lighting control design, and technology integration.

We examine every project with a comprehensive systematic approach to meet the client’s sustainability, energy, water and environmental quality goals.

S U S T A I NAB I L I T Y

ADVANCED SIMULATIONS

We provide various advanced computer simulations to study wind patterns, thermal stratification and comfort issues in spaces, building façade studies and energy modeling to aid architects and owners make key decisions during the early stages of design.

• Façade Engineering • CFD/Wind Studies • Thermal Stratification Studies • Energy Concept Studies • Energy Modeling

S U S T A I NA B I L I T Y

CASE STUDY:

UBER MB 1 & 2 MISSION BAY HEADQUARTERS

San Franc isco, CA

AlfaTech is currently involved in this Uber’s new San Francisco presence which is a new 420,000 square-foot, ground up office building in the Mission Bay area in San Francisco. Our scope of work includes mechanical, electrical, plumbing, technology, security, and sustainability services. AlfaTech assisted the architectural design team with optimizing performance by assessing various utility, façade and wind studies. The project is designed as an innovative, ultra- high performance building that includes a façade that responds to programmatic needs, an under floor air distribution system, a “winter garden” which acts as the main social space incorporating natural ventilation, and a proposed geothermal system to substantially reduce cooling equipment needs. AlfaTech has been providing MEP Engineering and Technology services for this client in the US and Globally for ten sites, including the new corporate headquarters in San Francisco. This is a state of the art new campus with over 420k SF of offices, a full kitchen and cafeteria. The project will include evaluation of all available sustainability features. Sustainability goals: • Significant reduction of building energy cooling needs by the use of geothermal exchange systems • Aggressive rainwater capture and retention • Natural ventilation for main atrium social areas, creating a pleasant, open experience for employees and visitors • Maximize use of day lighting to optimize workspace quality

S U S T A I NAB I L I T Y

CASE STUDY:

LENNAR CANDLESTICK POINT & HUNTER’S POINT MASTER PLAN San Franc isco, CA

The Candlestick Point and Hunter Point Shipyard is a 702-acre development that has the potential to bring most dynamic companies into the area and develop whole communities. This area will house R&D facilities, commercial spaces, multi- use buildings and retail spaces. Parks, trails, and open spaces will be additional features that will attract and enhance the community. The new development will add over 10,000 new residential units in the form of condominiums and low-, mid- and high-rise buildings. There will be over a million square feet of commercial space made available, over three million square feet for Research and Development, as well as over 300,000 square feet of property devoted to community activities. AlfaTech views this holistic approach to community development as an opportunity for Lennar Urban to be at the vanguard of urban design by creating a community infrastructure focused on environmental sustainability, technology, and self- sustaining. This means taking advantage of existing technologies to generate energy with the lowest environmental impact. We conducted a series of sustainable mechanical studies in a master plan scale to help the owners understand the options available to explore the feasibility of Net Zero energy for the new development. Proposed strategies involve:

• Geothermal heat rejection systems • High performance chillers and thermal energy storage • Biodigestion system for heat recovery and energy generation

• Solar photovoltaic array for electricity generation • Rainwater and gray water capture and treatment

S U S T A I NA B I L I T Y

CASE STUDY:

DELTA PRODUCTS HEADQUARTERS Fremont, CA

Delta Products desired a new headquarters highlighting sustainability and energy efficiency with primary goals to showcase Delta Products’ innovation in a state of the art building blending the natural surroundings with sustainable building design. The Delta Americas Headquarters is a three-story 250,000 SF campus consisting of private offices, administrative, open workspace, conference/auditorium facilities, kitchen/dining areas, labs, office and warehouse. AlfaTech provided sustainable mechanical electrical plumbing engineering design services for this project focusing on the client’s desire to maximize natural ventilation and daylighting reduce water and energy consumption with a geothermal central plant and utilize radiant systems for primary space conditioning. AlfaTech conducted extensive CFD modeling to assist with sizing and locating windows around the building and their integration into a thermal tower ventilation strategy. The project also encompasses a photovoltaic system to balance energy consumption and achieve Net Zero Energy.

Some of the features included are:

• Ecological ponds • EV chargers • Rainwater harvesting • Elevator power regeneration systems • Energy efficient HVAC system • Energy storage solutions • Hydronic bidirectional heating/cooling flooring systems

• Ground source heat pumps • Solar energy system • Natural ventilation • Active chilled beam • LED lighting • Spectrally selective glazing • Grass and native plants

We believe making the world a better place is a responsibility we all share. And being able to do our part in the way we work is one of the best ways we can give back and have a positive effect on our environment. This means, not only do we always strive to provide the most sustainable solutions for our clients, but we are also always working on new, innovative and pioneering methods to bring sustainability to the next level, staying ahead of the curve in all types of projects in all the markets we serve.

Let’s leave the world a better place than we found it.

03 MARKETS & Relevant Projects

LIFE SCIENCES

L I F E S C I ENC E S

AlfaTech offers a full range of professional engineering services from concept creation to commissioning and validation, including feasibility studies, condition assessments, planning, design, program management and construction period services. Our experienced professionals are expert in cGMP and GLP compliance and understand the difficult decisions Life Science facility owners make every day when choosing between economy and function. Our team has the experience and capabilities to address projects throughout our clients’ facilities from labs to manufacturing or corporate office and campus infrastructure. We have the capacity, experience and business structure that allows us to support a wide range of projects from the small consulting scope to ground-up campus projects. This combination of resources and skills provides a strong value proposition, predicated on innovative solutions and disciplined cost, quality and schedule management.

STRATEGIC PARTNER SERVICES Architectural Planning and Design Structural Engineering Process Controls Validation Site Civil Engineering

SERVICES Process Engineering Lab Planning and Design Master Planning Mechanical Engineering Electrical Engineering Structural Engineering Facility Condition Assessment

Site Selection Sustainability

FDA and EU Compliance Consulting Commissioning and Energy Solutions

L I F E S C I ENC E S

LABORATORIES Clinical GLP QC BSL 1, 2 and 3 Flexible Labs

GENERAL BUILDING / CAMPUS SYSTEMS AND SPACES Electrical Distribution (480V to Low Voltage Systems) Site Electrical Distribution Backup Generation UPS HVAC Technology Systems (Communication, AV, Security, WIFI) Lighting and Lighting Controls BMS/EMS Tank Farms and Utility Yards

PLANT AIR SYSTEMS Scrubbers Clean Rooms Room Pressure Profiles and Cascade HEPA Filtration Exhaust Hoods and Dust Collection Explosion Relief

cGMP COMPL IANT MANUFACTURING FACIL ITIES Pilot Plant Clean Rooms

PERMITTING AND REGULATORY COMPL IANCE FDA Inspection Readiness Support Air Permitting Support Code Analysis and Building Code Occupancy Issues Building Permit Administration and Support WASTE WATER AND HAZARDOUS WASTE TREATMENT Waste Treatment Process Design Recycling Systems Heavy Metals Removal and Neutralization Reverse Osmosis and Ultra Filtration Solids Removal Systems Biohazard Treatment and Detoxification Incineration

Truck Docks Warehouse Data Centers Corporate Office

Commercial Manufacturing Process Batching and Campaigning Areas Blending and Mixing Rooms Fill and Finish Wash Room Packaging and Labeling Production Equipment Specification Production Equipment Utility Hookup Isolation Technology Containment Facilities Gowning Rooms Warehouse and Material Handling

PROCESS AND BUILDING UTIL ITY SYSTEMS WFI

CIP and SIP Clean Steam Process Chilled Water RO/DI CDA Specialty Gases Lab Gases Solvent Systems Central Plants

RELEVANT PROJECTS

L I F E S C I ENC E S

BUCK INSTITUTE STEM CELL RESEARCH LAB

Novato ,CA

Type: Lab, Animal Handling facility Size: 60,000 SF

AlfaTech provided project management, as well as mechanical and electrical engineering services for this project. Systems include the addition of a ground coupled geothermal system, which provides heating and cooling to the new addition and the existing 60,000 SF lab facility. Geothermal ground water at 61 degrees will be used to condition lab fume hood make up air, freeing up 300 tons of cooling from the existing central plant. The additional chilled water tonnage will be used for the new addition. The new geothermal system will provide all cooling & heating for the existing & new 60,000 ft2 lab building, and “no additional tonnage” will be required for the existing central plant. The geothermal system will also save 7,500.000 gallons of water a year from being evaporated via the existing (now decommissioned) cooling towers.

L I F E S C I ENC E S

ABBVIE BIOTHERAPEUTICS (FORMERLY ABBOTT)

Redwood City, CA

Type: Data Center, Campus, Laboratory, Pilot Plant Size: 400,000 SF with central Data Center

AlfaTech was selected as a turnkey firm to design and build Abbott's 400,000 SF new headquarters campus. The facility now houses an Abbott spinoff company called AbbVie. This project includes a 4,000 SF raised floor data center, tenant improvement of offices, along with laboratory facilities, and vivarium (animal care facility). A pilot plant (cell culture and purification) was built on the first floor along with new laboratory facilities, offices, and service yard. AlfaTech was fully responsibly for programming, design and construction of this state-of-the-art campus for which the budget and schedule was guaranteed as a part of our highly successful single-source project delivery method.

L I F E S C I ENC E S

STANFORD UNIVERSITY CLARK CENTER R&D FACIL ITY

Palo Alto, CA

Type: R&D Laboratory Size: 200,000 SF

This 200,000 SF project is a multi-story building on the Stanford University campus dedicated to biotechnology research and development. The firm was responsible for the design of the HVAC, fume exhaust, building automation, and peer review of the plumbing/process piping systems.

L I F E S C I ENC E S

ALZA

Various Bay Area Sites

Type: Laboratories, cGMP Manufacturing, Vivarium, Office, Pilot Plant Size: 1, 000,000+ SF

Sampling of Projects:

Vacaville cGMP Facilities: • Original Manufacturing Building • Aqueous Tablet Coater • Fluid Bed Dryer • High Shear Granulation • Pharmaceutical Processing Area • Tablet Coating Process • Methylene Chloride Distribution Mountain View Facilities: • Buildings M2 & M3 Biocenter • M1 Pilot Plant & Research Center

Palo Alto Facility: • Buildings M8 & M9 • Underground Tanks

AlfaTech and AlfaTech team members have provided design services for various Bay Area sites listed above.

L I F E S C I ENC E S

GENENTECH

South San Francisco, CA

Type: Office , Laboratory, cGMP Manufacturing Size: 100,000 SF

AlfaTech provided a new $1.1 million, 2-story facility for animal research labs and support areas. The mechanical design features double-duct, double-fan, constant volume mixing boxes with HEPA filtration. In addition, the firm provided full facility design services for Genentech’s Vacaville campus under a Master Services Agreement. This work encompasses office space, laboratory and cGMP manufacturing.

GENENTECH* South San Francisco, CA

Type: R&D Laboratory

Small Portfolio Program ($10 mm and less construction value). Supported Genentech’s Small Project Portfolio program for the pharmaceutical research and manufacturing company’s South San Francisco Campus. Provided Architecture and Engineering planning, design and construction support for a wide variety of facility projects including research labs, GMP cold room upgrades, building condition assessment and upgrades, waste stream compliance and utility systems. Utility systems include electrical infrastructure, steam, compressed air, exhaust, fire suppression, domestic water, sanitary sewer, chilled water and plant gases

* Completed by AlfaTech principal during previous employment

L I F E S C I ENC E S

MASSBIOLOGICS VIRAL VECTORS* Fall River, MA

Type : Bioprocessing Facility

The MassBiologics South Coast Facility in Fall River, MA is a bioprocessing facility located on a four-acre green field site within the newly developed 300 acre Fall River Executive Park near State Route 24. The building contains administration offices, conference rooms, and staff support areas. The facility included a mechanical mezzanine structure above a section of the bioprocess area to house process utilities and HVAC units. The basement level area contains liquid waste collection and treatment systems, as well as a plant steam system and boiler plant. Use of gene therapy vectors using AAV approach.

* Completed by AlfaTech principal during previous employment

L I F E S C I ENC E S

MASSBIOLOGICS cGMP CULTIVATION SUITE* Boston, MA

Type : cGMP Manufacturing Size : 2,700 SF

MassBiologics constructed and commissioned a new 2,700 sf cGMP manufacturing area within the Mattapan II Facility (MTP2) for cultivation of toxins used to manufacture Tetanus and Diphtheria Toxoids Adsorbed (Td) vaccine. Since the toxin, Clostridium tetani is a spore-forming organism, the area design, controls and monitoring are based on FDA industry guidance document: “Manufacturing Biological Intermediates and Biologic Substances using Spore-Forming Microorganism” dated September 2007. The Culture Area is located in the basement of the MTP2 building along with process utilities and storage areas. Additional offices, IT server data center and a mechanical area containing HVAC is located on the second floor. The new Culture Area contains an IND Cell Bank room for the manufacture of mammalian and non-Td GMP cell banks.

Engineered Systems Designed Include

• Clean room design • Single pass HVAC system • Spore and No-spore Laboratory spaces • RO/DI system • WFI system • Water Reclamation • BL-2 Labs

* Completed by AlfaTech principal during previous employment

L I F E S C I ENC E S

GILEAD SCIENCES

Foster City, CA

Type: Office, Laboratory, cGMP Manufacturing, Pilot Plant, Campus Size: 500,000 SF

AlfaTech provided MEP and telecommunications design for Gilead’s campus consisting of 16 buildings including administrative and private offices, pharmaceutical development processing suites, pilot plants and cGMP therapeutic manufacturing / production areas.

New Systems include: • Process Vacuum System • Nitrogen System • Process Compressed Air System • Cooling System • Dust Collection System

• Exhaust System • System Controls

• Air Shower System • USP Water System • RO/DI Water System • Domestic Water System • N2 Gas System

• Process Waste System • Building Service System • Emergency Power System • Distribution System • Class II Hazardous Locations (Granulation and Drying, Milling and Blending, Tablet Coating, Tablet Compression, Weigh Room) The firm also provided MEP engineering design services for Gilead’s 35,000 SF pilot plant on the Foster City campus as part of a previous project.

L I F E S C I ENC E S

GENENCOR

Palo Alto, CA

Type: Offices, R&D Laboratory, Pilot Plant Size: 77,500+ SF

This International Technology Center facility combines basic research, pilot plant development, and robotics under one roof. This cGMP project required complete equipment layout, installation design for a pre-manufactured fermentation skid, tank design, and design of three automated 1,500-liter recovery vessels.

L I F E S C I ENC E S

BIOMARIN PHARMACEUTICAL GALL I EAST EXPANSION (BGEX)

Novato, CA

Type: cGMP Manufacturing Size: 20,000 SF

AlfaTech’s services included management oversight of facilities operations for the manufacturing plant during facility validation. Scope included management of standard operating procedures, spare parts, training of new systems, turnover of systems and facility from contractor to BioMarin and plant engineering services.

BIOMARIN PHARMACEUTICAL* 95 Digital East Laboratory Build-out, Novato, CA

Type : R&D Laboratory

Engineering Design of HVAC, process systems and piping including process cooling water (PCW), clean in place (CIP) systems, deionized water (DI), water for injection (WFI), clean dry air (CDA) and plumbing for build out of shell space to new R&D laboratories.

BIOMARIN PHARMACEUTICAL* Novato, CA

BioMarin executed a utility yard expansion to accommodate additional capacity for lab and manufacturing facilities. The project included specification and conceptual design for addition of a 400-ton chiller to an existing 1000-ton system and 7,000 lb steam boiler to an existing 125 psig plant steam system. The scope also included design of a new enclosed two-story plant utility yard structure with architectural finishes to match the existing building. Challenges included design of new distribution piping to connect new equipment to the existing chilled water and plant steam systems, accommodation of existing equipment including emergency generator and water treatment systems as well as the facility’s loading dock.

* Completed by AlfaTech principal during previous employment

L I F E S C I ENC E S

SOKA UNIVERSITY OF AMERICA

Aliso Viejo, CA

Type : Campus Expansion, Labs Size : 200,000 SF

AlfaTech is providing mechanical, electrical, and plumbing design services for this university campus expansion project located near Irvine, CA. The Engineering / Science / Lab / Admin Building will be 4 stories and approximately 100,000 SF with classrooms, administrative offices, and wet and dry labs. The Resident Housing facility will be 4 stories and comprised of approximately 75 to 80 rooms. Both proposed projects will be designed to accommodate a LEED Gold Building Certification, and an exterior architectural design pallet that will respect the current design features, landscaping and cultural aspects of the campus.

L I F E S C I ENC E S

BAYER HEALTHCARE

*BAYER HEALTHCARE B14 HVAC Upgrade, Berkeley, CA

M C GUFF PHARMACEUTICAL* Compounding & Filling (503a &503b) Facility Master Plan Santa Anna, CA

Berkeley, CA

Type: Manufacturing Plant Size: 40,000 SF

The goal of this project was to improve occupant comfort and the energy profile of the nearly 100-year-old Building B14 which was being used by research team for critical future drug products. Project challenges included very limited capital available and architectural constraints of a building constructed before HVAC systems were invented such as low ceilings, and no interstitial space. The project team the Target Costing methodology to prioritize the design features in order to stay within budget as a result of early collaboration between the design team, the contractor, the site facility team and the end user. Project features included replacement of existing air handlers, replacement of windows to reduce heat gain and careful HVAC zoning within the space. The project required detailed implementation planning as the project was installed over several budget years.

Responsible for Master Planning, Options Development, Programming, and Conceptual Design for two separate facilities, 503a &503b. On a Greenfield 80,000 SF & 60,000 SF XOMA THERAPEUTICS Berkeley, CA

AlfaTech was selected to perform design construction management services for the replacement and upgrade of the B55 WFI system. The state-of-the- art replacement WFI system consisted of a single HWFI loop with multiple POU heat exchangers. WFI temperatures at the POUs were controlled using HMI panels. The firm scope of work included: interviews with the users to determine WFI consumption; production of complete WFI design-built and demo bid packages; procurement of owner-furnished components; selection of a design-built contractor; and management of the final design and construction effort.

Type: cGMP Warehouse , Manufacturing, Research, Pilot Plant Size: 8,000 SF and 10,000 SF

For the Pilot Plant, the project includes conversion of the X-5 pilot plant to a combination of manufacturing and research. Modifications were made to the existing facility, bringing it to current ADA standards, and generally “state-of- the-art” status. For the cGMP warehouse facility, the firm provided full design services which entailed the renovation of an existing facility along with validation support and construction management. The warehouse concept entailed the renovation of an existing facility along with validation support.

THE JACKSON LABORATORY WEST West Sacramento, CA

BAYER HEALTHCARE* Various Projects, Berkeley, CA

Type: R&D Laboratory, Vivarium Size: 91,000 SF

This project involved the relocation of Bayer’s BioAnalytics lab necessitated by the planned demolition of the aging building housing the original lab. The project included redesign of the lab layout to improve workflow and accommodate lab analytical equipment and sample storage freezers, design of gas utilities, wet utilities and waste, electrical power and lighting, cabinetry and architectural finishes. NEKTAR THERAPEUTICS San Carlos, CA

AlfaTech provided MEP design services for interior improvements to an existing tilt-up concrete warehouse, as well as an expansion into an existing facility. The new use of this space includes West Coast regional offices, animal vivarium, wash/sterilization facilities, various research laboratories, animal shipping/staging/support spaces, mechanical yard, and parking .

XOMA THERAPEUTICS Berkeley, CA

Type: GMP & cGMP Fermentation Suite Size: 5,000 SF and 12,000 SF

For the 5,000 SF Fermentation Suite, AlfaTech provided full design and construction management for its GMP new 2,000 liter fermentation suite along with validation support. Design for the 12,000 SF Suite provided a new cGMP fermentation suite consisting of 50 L, 130L, 500L, 2750L, and 12,000L fermenters. These were fully automated with CIP and SIP capability. In addition, a number of media preparation and purification vessels were specified.

BBRAUN* Site Master Planning, Irvine, CA

Type: Laboratory, Office, Manufacturing Size: 4,000 SF

Responsible for the Site Master Planning Options development and the Facility Planning, Evaluation of criteria and constraints, Developing Options for Steering committee selection. Projected $300 million project

AlfaTech provided design services for the consolidation of the central data center, which will occupy approximately 4,000 SF in a currently unoccupied space for Building 3.

* Completed by AlfaTech principal during previous employment

L I F E S C I ENC E S

OREAD

JRH BIOSCIENCES Woodland, CA

AMGEN BUILDINGS 31 AND 42 Thousand Oaks, CA Type: cGMP Manufacturing, Office Size: Building 31, 10,000 SF; Building 42, 15,000 SF

Palo Alto, CA

Type: Laboratory & Manufacturing Size: Robotics Lab, 1,000 SF, Chemistry Lab, 10,000 SF Facilities:

Type: Manufacturing Plant, R&D Laboratory Size: 30,000 SF

This facility produces media for cell metabolism studies and growth kinetics. It is also used for the research, development and manufacture of proprietary client products. Process piping included a WFI system with a high temperature (85°C) and ambient (25°C) loop and all necessary controls; a clean steam and plant system complete with boiler feed water pump system and blow down cooler; R.O. piping loop and system; process cooling water system with fluid cooler and chilled water heat exchanger; and process gases.

Amgen is a global biotechnology company that discovers, develops, manufactures and markets cost-effective human therapeutics based on advances in cellular and molecular biology. A large-scale dispensing suite was added to Building 31, and Building 42 was a new cGMP raw material receiving facility. On Building 31, AlfaTech provided mechanical, electrical, plumbing, support utility design, specifications, and specialized equipment sourcing for construction of cGMP raw material dispensing suites within an existing warehouse and distribution facility. Building 42 was programmed and designed for cGMP raw material receiving and support for Building 23, a clinical trial manufacturing facility. Process engineering design included liquid caustic solution receiving, storage and transfer systems, and fresh and waste glycerol streams storage and transfer systems.

• Chemistry Lab • Robotics Lab • WFI/USP Water System

Oread is a contract provider of comprehensive contract drug development, clinical trial support, finished product manufacturing and packaging, and regulatory support for the pharmaceutical industry. AT provided full engineering services for a robotics dissolution laboratory and the installation of a new formulation chemistry facility with a cGMP WFI system (1,000- gallon storage capacity). Extensive fume hoods contain MRI lab system and sterilizer. AT worked closely with the client during the programming phase and to make sure that the robotics facility, which features a robotically-controlled vial-fill system, would be validatable. The firm also managed the preparation of mechanical, electrical, plumbing, and process designs to meet city permit deadlines.

ARADIGM Hayward, CA

Type: cGMP Pilot Manufacturing Plant Size: 20,000 SF

Aradigm is engaged in the development of novel pulmonary drug delivery systems designed to enhance the delivery and effectiveness of a number of existing and development stage drugs and reduce the need for injectable drug therapy. Clinical trial Phase III quantities of three new products for inhalation therapy will be produced at the new full-scale cGMP clinical and manufacturing facility. AlfaTech also provided services at Aradigm’s 30,000 SF production facility. The project has extensive clean rooms, including Class 100 laminar flow processing areas; a WFI generation and distribution system; and high purity gas distribution.

BRISTOL-MEYERS SQUIBB* Redwood City, CA

SLAC NATIONAL ACCELERATOR LABORATORY Palo Alto, CA

This project consisted of replacement of an aging and inefficient chilled water system serving Autoclaves in the facility’s vivarium. A key project challenge included addressing a widely variable load. The chiller was specified with three compressors to allow efficient coverage of the loads.

Type: FEH Hutches 4, 5, &6

AlfaTech provided a feasibility study for the FEH Hutches 4, 5 and 6 project to define alternate system solutions for the HVAC design. The project was in the final design phase using a single unit air handling system. The distribution system was going to occupy space that the owner wanted to reserve for future use. We provided a conceptual design study to evaluate how much space could be saved using a different system. The study included pros and cons of each system, sketches for cost estimating and peer review of existing design documents.

* Completed by AlfaTech principal during previous employment

L I F E S C I ENC E S

VIVUS

NOVARTIS (CHIRON)* Vacaville, CA

JANSSEN PHARMACEUTICALS* Vacaville, CA

Lakewood, NJ

Type: Laboratory, Manufacturing Size: 80,000 SF

Type : VMF OLWX Project Manufacturing Facility Expansion Size: 17,000 SF, two-story building

Numerous upgrade and expansion projects were executed throughout all aspects of the facility including labs, manufacturing process and HVAC systems and building utility upgrades, manufacturing clean room projects, site infrastructure and utilities and administrative tenant improvements. Projects included: • Multi-year plantwide HVAC system renovation and replacement to modernize the plant’s clean room HVAC systems and to meet cGMP requirements. • Process Dust Collection System collecting hazardous dust produced pharmaceutical product manufacturing. • Manufacturing Suite projects to accommodate new products and processes including suite workflow layout, utility system design (electrical, O2, AOF, N2, chilled water, clean steam, etc.), waste streams, Architectural improvements. • Regenerative Thermal Oxidizer • Manufacturing Equipment Safety Upgrades to meet J&J Corporate safety standards • Raw Materials Warehousing and Lab • 1MW Solar Farm Condition Assessment and Upgrades • Manufacturing Washrooms • QC Labs

AlfaTech acted as the owner’s principal engineer for design of a facility that expanded their capacity to formulate and produce a new drug and drug delivery system. The scope of work involved HVAC, process utilities, R.O./D.I. and hot USP water systems, production room layout, and general engineering support. AT also worked closely with the validating agency to provide a complete turnover package.

Full Civil and MEP design services for a 17,000 SF two-story building expansion. The expansion included private offices, open office areas, meeting, conference and storage rooms, corridors, stairs, restrooms, elevator, QA/QC engineering document storage room, QC and raw materials laboratories and process equipment storage, in the following cGMP areas: weigh/dispense room, quarantined and released materials.

BAXTER HEALTHCARE Hayward, CA

NOVARTIS (CHIRON)* San Carlos, CA

Type: cGMP Laboratory

This Hyland Division Laboratory renovation project involved a complete remodel and relocation of the biotechnology process rooms. Construction documents and validation for a cGMP upgrade of the existing facility were also required.

Engineering Design for multiple facility projects including: • Temperature Control for CSD-1 Dryer • Laboratory Humidification System Replacement • Site Energy Manager (Staff Augmentation) • Sitewide Electrical Power Study and Maintenance Plan • Niro-2 Exhaust Modifications (Design/Build Project Delivery)

COLLAGEN AESTHETICS INC. Fremont, CA Type: Manufacturing Plant Size: 12,000 SF Facilities: • Bulk Processing Area Addition • Office Space Tenant Improvements • Warehouse and Office Space

• Code Studies • Data Center

NOVARTIS (CHIRON)* Emeryville, CA

PAR, FAIRBANK OSD* Facility Master Plan, Irvine, CA

Architecture and Engineering Design for multiple facility projects including: • Site Wide Energy Efficiency Study • Building 4 Lab Tenant Improvements • Robotics Lab Tenant Improvements • Building 4 Executive Conference Center • Building G&T Chilled Water System Upgrades Concept Design

Responsible for Master Planning, Options Development, Programming, and Conceptual Design of the facility. For an existing 90,000 SF OSD Facility that includes manufacturing, QC lab, lab support, warehousing and administrative functions

Collagen Aesthetics Inc. develops, manufactures, and markets on a worldwide basis high quality biocompatible products for the treatment of defective, diseased, traumatized or aging human tissues. This project modified existing Class 100 – 10,000 spaces for laminar flow filling suites for new product manufacturing. The firm maintains Collagen’s library of as-built drawings to support ISO 9001 certification.

* Completed by AlfaTech principal during previous employment

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