AlfaTech Big Book – Life Sciences

INNOVATIVE IDEAS | INTEGRATED SOLUTIONS | SUSTAINABLE PARTNERSHIPS

01

OVERVIEW / Profile & Services

02 Sustainability

03

Markets & Relevant Projects

Life Sciences

OVERVIEW 01

Profile & Services

P R O F I L E

ALFATECH

AlfaTech has built a reputation over 30+ years providing the most innovative and sustainable engineering solutions starting at the master planning phase and continuing through construction administration. Our clients include high tech clients, service firms, large organizations in various industries, local and multi-national companies, and many ongoing clients we’ve been serving for years. We provide intelligent and cutting edge design at every turn, beginning at the commencement of every project in order to provide maximum benefit to our clients through the entire process. Our engineering solutions are highly efficient and cost effective, and ensure clients the greatest possible return on investment. Overall, we strive to develop the most dynamic relationships, be attentive to the needs of our clients and partners, and be true team players. With this mindset, we’ve proudly built a stellar list of clients.

RSBG COMPANIES

AlfaTech is part of a network of experienced companies that provide relevant services across the globe. These firms possess the most innovative and brightest talent which ensures the most forward thinking solutions and services for all projects in all the markets we serve. These companies operate from numerous offices in Europe, the Middle East, Asia and Africa. Now with over 6,400 staff members worldwide and in over 30 countries we

can serve all of our clients’ needs. . . . . . . . . . . . . . . . . . . . . . . . . . . . .

Collectively, the expertise of AlfaTech and RSBG provides engineering solutions that augments the vision of our clients and enables the most groundbreaking workplaces that go beyond current trends, and enable all future-of-work strategies.

AbbVie Biotherapeutics

P R O F I L E

US San Jose, California

San Francisco, California Los Angeles, California Ventura, California San Diego, California Monrovia, California Atlanta, Georgia Edison, New Jersey

EUROPE Vienna, Austria Le, Denmark Paris, France Berlin, Germany

MIDDLE EAST Doha, Qatar Madiant Zayad, UAE Abu Dhabi, UAE

Al Ain, UAE Dubai, UAE Baghdad, Iraq Amman, Jordan

Bochum, Germany Frankfurt, Germany Hamburg, Germany

Munich, Germany Rostock, Germany Stralsund, Germany Ribnitz-Damgarten, Germany Wiesbaden, Germany Cologne, Germany Athens, Greece Madrid,Spain Zurich, Switzerland

Jeddah, Saudi Arabia Riyadh, Saudi Arabia

AFRICA Beau Bassin, Mauritis Cairo, Egypt Algeria Libya Sudan

Istanbul, Turkey Birmingham, UK Bishop’s Strotford, UK Croydon, UK Edinburgh, UK Exeter, UK Leamington Spa, UK Leeds, UK London, UK Luton, UK

ASIA Brahmanbaria, Bangladesh Dhaka, Bangladesh Dehradun, India Delhi, India Gandhingar, India Mumbai, India New Dehli, India

Pune, India Rajkot, India

Maidenhead, UK Manchester, UK Nottingham, UK Stockport, UK Sunderland, UK Wakefield, UK

Visakhapatnam,India Manilla, Philippines Singapore, Singapore Bangkok, Thailand

L E A D E R S H I P

JEFF F INI , P E , MB A F ound e r a nd Ch a i rma n

T IM CHADWICK , P E , L E E D A P C EO , S a n J o s e Me c h a n i c a l E n g i n e e r

V I C A. S I B I LLA, P E , L E E D A P Ch i e f S t r a t e g y a nd De v e l opmen t O f f i c e r

DIARMUID HARTLEY , L E E D A P Ma n a g i n g P a r t n e r , L o s An g e l e s Me c h a n i c a l E n g i n e e r

SAI ED NAZERI , P E , C PD , L E E D A P Ma n a g i n g P a r t n e r , S a n F r a n c i s c o Me c h a n i c a l E n g i n e e r

TERRY STELTER S en i o r P r i n c i p a l , S a n J o s e L i f e S c i en c e s

KEVIN KEYFAUVER, PE, LEED AP Ma n a g i n g P a r t n e r , Mon r o v i a Me c h a n i c a l E n g i n e e r

GERALD D. HARTFORD, JR , P E , L E E D A P , G PD Ma n a g i n g D i r e c t o r , S a n D i e g o Me c h a n i c a l E n g i n e e r

R I CH GARRI SON Ma n a g i n g P a r t n e r T e c hno l o g y

EL I ZABETH MONT I , MB A S en i o r P r i n c i p a l , Co r po r a t e Bu s i n e s s De v e l opmen t

V INCE TARANGO , I E S , I A L D A r c h i t e c t u r a l L i g h t i n g S ou t h e r n C a l i f o r n i a

ROHINI PENDYALA, M I E S A r c h i t e c t u r a l L i g h t i n g No r t h e r n C a l i f o r n i a

MA R K E T S

MA R K E T S

MEDIA + ENTERTAINMENT

CORPORATE TI + CAMPUS

AVIATION

HEALTHCARE

K – 12 EDUCATION

CULTURAL + SPECIAL PROJECTS

HIGHER EDUCATION

PUBLIC / CIVIC

RESIDENTIAL + MULTIFAMILY

INDUSTRIAL / MANUFACTURING

MISSION CRITICAL

LIFE SCIENCES

S E R V I C E S

MECHANICAL ENGINEERING DESIGN HVAC

ARCHITECTURAL LIGHTING DESIGN Lighting and Lighting Controls Lighting Calculations

COMMISSIONING | ENERGY SOLUTIONS Early Quantifiable Energy Study Incentives

Heating Systems Water and Gas Cooling Systems / Chilled Water Dehumidification Systems Contamination Sensitive Areas Industrial Hygiene Systems Low Tolerance Temp Control Title 24 Analysis and Design Heat Recovery Systems Central Utility Plants Air Handlers HVAC System Controls PLC Programming Fire Protection and Plumbing

Customized ROI Calculations Sustainable Lighting Design Energy Savings Analysis Custom Lighting Fixtures Custom Lighting Fixtures Design

Energy Star® Assessments Retro-commissioning (RCx) Monitoring Brand Continuous Commissioning (MBCCx) ASHRAE Level 1, 2 and 3 Energy Audits Measurement and Verification (M&V) of installed projects Energy Modeling Net Zero Energy Budgeting HVAC/Chilled Water Plant Optimization

TECHNOLOGY DESIGN Low Voltage Design Audio Visual Design

Security Systems Design Architectural Acoustics Wireless Design & Modeling Distributed Antenna Systems (DAS) Integrated Building Management Systems BMS Network Integration Telco Facilities and Services Voice Systems and Applications Relocation & Data Center Migration Services Strategic Planning and Analysis Project Management Management Consulting SUSTAINABILITY Sustainability Planning (Organizational and Infrastructural) LEED / Green Building Consulting Masterplanning Life Cycle Cost Assessment Occupant Wellness and Comfort

PROCESS Industrial Waste Collection Acid Neutralization Bio-Kill Waste System Process Waste Containment Ultra pure De-ionized Water Systems USP Water WFI Specialty Chemicals Chemical Storage

ELECTRICAL ENGINEERING DESIGN Power Systems

Emergency & Standby Power Lighting and Lighting Controls Security Systems 24 / 7 Power Systems (UPS) Power Monitoring Systems Toxic Gas Monitoring Graphic Control and Alarm Panels Grounding and Bonding

Lab and Special Gas Systems Ultra High Purity Gas Piping

Bulk & Specialty Gases Toxic Materials Handling Code Compliance Process Distribution Piping Process Cooling Water Medical Gas Medical Vacuum Waste Anesthetic Gas Disposal system (WAGD) Dental Vacuum System Dental Water System

Energy Management Energy Conservation Fire Alarm Systems Public Address Systems Plug Loads Control

Façade Engineering CFD / Wind Studies Wind Studies Thermal Stratification Studies Energy Concept Studies

S E R V I C E S

GREEN BUILDING

SUSTAINABILITY

PLANNING

LIFE

PROCESS ENGINEERING DESIGN

OF A BUILDING

MECHANICAL ENGINEERING DESIGN

ELECTRICAL ENGINEERING DESIGN

ARCHITECTURAL LIGHTING

TECHNOLOGY

RETRO COMMISSIONING

COMMISSIONING / ENERGY SOLUTIONS

CONS TRUCT I ON

OCCUPANCY

END OF US E

DES I GN

SUSTAINABILITY 02

S U S T A I N A B I L I T Y

AlfaTech follows a holistic approach to meet project expectations in all dimensions. Providing sustainable design is an achievement if it is also functional. Increasing efficiency is realistic when it is applicable. Meeting the project budget is possible when the design is constructible.

We take pride in our designs and ensure that the following principles are aligned in our approach to every project:

• Implementing sustainable solutions • Environmental awareness and reducing carbon footprint • Creating a stress-free, comfortable and healthy environment • Optimizing building performance, reducing energy and water usage • Utilization of the latest smart building technology and occupant environmental control, including temperature control, lighting control, building envelope shading, acoustic and air quality by means of enhanced filtration system At AlfaTech, we have a multidisciplinary team of experts to assess and design projects with an integrated approach. Working along with owners, architects and other stakeholders, we examine every project with a comprehensive, systematic approach to meet the client’s sustainability, energy, water and environmental quality goals. AlfaTech goes beyond engineering – our suite of energy, water and sustainability assessment services creates projects that benefit the triple bottom line – people, planet and profit. We provide expert studies in all qualitative aspects of the built environment such as day lighting, thermal comfort, advanced lighting control design, and technology integration.

We examine every project with a comprehensive systematic approach to meet the client’s sustainability, energy, water and environmental quality goals.

S U S T A I N A B I L I T Y

ADVANCED SIMULATIONS

We provide various advanced computer simulations to study wind patterns, thermal stratification and comfort issues in spaces, building façade studies and energy modeling to aid architects and owners make key decisions during the early stages of design.

• Façade Engineering • CFD/Wind Studies • Thermal Stratification Studies • Energy Concept Studies • Energy Modeling • Daylighting Modeling

S U S T A I N A B I L I T Y

CASE STUDY:

UBER MB 1 & 2 – LEED PLAT INUM / WELL GOLD MI SS ION BAY HEADQUARTERS

San F ranc i sco, CA

AlfaTech is currently involved in Uber’s innovative new San Francisco headquarters which is a new 420,000 square-foot, ground up office building in the Mission Bay district. We provided design/bid/build style Mechanical, Electrical, and Plumbing (MEP) engineering, lighting design, and Technology (low voltage, security, audio/visual) services, throughout the entire project. AlfaTech is part of the construction administration effort and served as the engineer-of-record for mechanical and electrical installations. We assisted the architectural design team with optimizing performance by assessing various utility, façade and wind studies. Life-cycle cost analysis, energy benchmarking, and computational fluid dynamics were critical tools to inform the design effort. The project is designed as an innovative, ultra-high performance building that focuses on an occupant-centric workplace and includes an elaborate IT infrastructure, a façade that responds to programmatic needs, an under floor air distribution system, a two-building atria system incorporating natural ventilation, and a central treatment system for collecting graywater and rainwater. The interactions between the occupants, the buildings, and the ambient, were at the heart of the architectural and engineering systems; targeting lower environmental metrics of 1,100,000 kWh in reduced energy use and 2,100,000 gallons in reduced water use.

• High-performance LED lighting with an occupancy driven network-based lighting control • Fuel cells redundantly powering building network operations • Solar domestic hot water system • PV-ready electrical system • Integrated building management system, including Smart Building Technology

• Significant reduction of building energy by means of combined hydronic chill beam and underfloor air system (UFAD) • Aggressive rainwater capture and retention. • Graywater reuse • Natural ventilation for main atrium social areas, creating a pleasant, open experience for employees and visitors. • Maximize use of day lighting to optimize workspace quality.

S U S T A I N A B I L I T Y

CASE STUDY:

LUCAS MUSEUM OF NARRAT IVE ART Los Ange l es , CA

The Lucas Museum was conceived with the bold ambition to challenge the way our societies appreciate art museums. Inspired by its resolute mission, the engineering design blasted off with the vision to deliver a lasting, centenarian building in harmony with its site. The carbon zero design harnessed heat and cooling from the soil beneath the museum with over 700 vertical bores. This constituted the deepearth, pulsating aorta of the geothermal field. A second element of nature was introduced by way of a thermally active water pond, which increased the site’s innate cooling capacity. These features were modulated by the high-efficiency, heat recovery central plant that provided all-electric, simultaneous heating and cooling (and no gas-fired boilers). Environmental quality for prime spaces – galleries, state of the art theaters, and lobbies – were controlled with underfloor air-distribution and radiant floors. Smart controls gently nudged temperature and ventilation parameters to adjust to visitors’ comfort. The superstructure lifted off with an exterior façade that self-shaded the thermal shell, effectively reducing cooling demand. Curved onyxglass organically traced the rooftop which formed the solar PV field. At 365 kW capacity, the renewable energy source reduced an estimated 10-15% of the electricity demand and swung the carbon footprint negative. Ahead of its time, the Lucas Museum will open the doors as an eco-friendly, ‘net zero energy’-ready museum that gives back to the surrounding community.

• Geothermal loop • A solar energy system • Natural ventilation • Displacement system • LED lighting • Spectrally selective glazing

• Grass and native plants • Ecological ponds • EV charger • Rainwater harvesting • Energy efficient HVAC system • Hydronic bidirectional heating/cooling flooring systems

S U S T A I N A B I L I T Y

CASE STUDY:

DELTA PRODUCTS HEADQUARTERS F remont , CA

Delta Products desired a new headquarters highlighting sustainability and energy efficiency with primary goals to showcase Delta Products’ innovation in a state of the art building blending the natural surroundings with sustainable building design. The Delta Americas Headquarters is a three-story 250,000 SF campus consisting of private offices, administrative, open workspace, conference/auditorium facilities, kitchen/dining areas, labs, office and warehouse. AlfaTech provided sustainable mechanical electrical plumbing engineering design services for this project focusing on the client’s desire to maximize natural ventilation and daylighting reduce water and energy consumption with a geothermal central plant and utilize radiant systems for primary space conditioning. AlfaTech conducted extensive CFD modeling to assist with sizing and locating windows around the building and their integration into a thermal tower ventilation strategy. The project also encompasses a photovoltaic system to balance energy consumption and achieve Net Zero Energy.

• Two passively conditioned, interconnected atria • Shaded facade with automated natural ventilation • Chilled sails and occupant- controlled underfloor air- distribution systems • High-performance LED lighting with an occupancy driven network-based lighting control

• Graywater reuse and rainwater catchment systems • Integrated building automation, controls and management platforms • Full air-side and water-side economizing • Fuel cells redundantly powering building network operations • Solar domestic hot water system • PV-ready electrical system

We believe making the world a better place is a responsibility we all share. And being able to do our part in the way we work is one of the best ways we can give back and have a positive effect on our environment. This means, not only do we always strive to provide the most sustainable solutions for our clients, but we are also always working on new, innovative and pioneering methods to bring sustainability to the next level, staying ahead of the curve in all types of projects in all the markets we serve.

Let’s leave the world a better place than we found it.

03 MARKET

& Relevant Projects

LIFE SCIENCES

L I F E S C I E N C E S

AlfaTech offers a full range of professional engineering services from concept creation to commissioning and validation, including feasibility studies, condition assessments, planning, design, program management and construction period services. Our experienced professionals are expert in cGMP and GLP compliance and understand the difficult decisions Life Science facility owners make every day when choosing between economy and function. Our team has the experience and capabilities to address projects throughout our clients’ facilities from labs to manufacturing or corporate office and campus infrastructure. We have the capacity, experience and business structure that allows us to support a wide range of projects from the small consulting scope to ground-up campus projects.

This combination of resources and skills provides a strong value proposition, predicated on innovative solutions and disciplined cost, quality and schedule management.

SERVICES Process Engineering Lab Planning and Design Master Planning Mechanical Engineering Electrical Engineering Structural Engineering Facility Condition Assessment

STRATEGIC PARTNER SERVICES Architectural Planning and Design Structural Engineering Process Controls Validation Site Civil Engineering

Site Selection Sustainability

FDA and EU Compliance Consulting Commissioning and Energy Solutions

L I F E S C I E N C E S

LABORATORIES Clinical GLP QC BSL 1, 2 and 3 Flexible Labs

GENERAL BUI LDING / CAMPUS SYSTEMS AND SPACES Electrical Distribution (480V to Low Voltage Systems) Site Electrical Distribution Backup Generation UPS HVAC Technology Systems (Communication, AV, Security, WIFI) Lighting and Lighting Controls BMS/EMS Tank Farms and Utility Yards

PLANT AIR SYSTEMS Scrubbers Clean Rooms Room Pressure Profiles and Cascade HEPA Filtration Exhaust Hoods and Dust Collection Explosion Relief

cGMP COMPL IANT MANUFACTURING FACI L ITIES Pilot Plant Clean Rooms

PERMITTING AND REGULATORY COMPL IANCE FDA Inspection Readiness Support Air Permitting Support Code Analysis and Building Code Occupancy Issues Building Permit Administration and Support WASTE WATER AND HAZARDOUS WASTE TREATMENT Waste Treatment Process Design Recycling Systems Heavy Metals Removal and Neutralization Reverse Osmosis and Ultra Filtration Solids Removal Systems Biohazard Treatment and Detoxification Incineration

Truck Docks Warehouse Data Centers Corporate Office

Commercial Manufacturing Process Batching and Campaigning Areas Blending and Mixing Rooms Fill and Finish Wash Room Packaging and Labeling Production Equipment Specification Production Equipment Utility Hookup Isolation Technology Containment Facilities Gowning Rooms Warehouse and Material Handling

PROCESS AND BUI LDING UTI L ITY SYSTEMS WFI

CIP and SIP Clean Steam Process Chilled Water RO/DI CDA Specialty Gases Lab Gases Solvent Systems Central Plants

L I F E S C I E N C E S

CONF IDENTIAL CL IENT | COVID19 TESTING LAB (BSL2)

Sunnyvale, CA

Type: Office, R&D

Major e-commerce client approached AT in Mid-April to aggressively install onsite virus testing labs. Parallel development of mobile modular labs and TI / brick and mortar labs for COVID19 testing. Satellite locations throughout the US are being established for quick testing turnaround following Federal CDC guidelines for virus testing labs which are BSL-2 biosafety level. Established laboratory operations and PCR processes to help control contamination. Develop a (1) line (1,000 samples), (2) line (7,500 samples) and (4) line (estimated 20,000 samples daily). Mechanical Team provided 15 ACH 100% exhaust with the DOAS and used cascade pressurization with the testing part of the lab being the most negative with pre-testing room second most negative, while pressurizing all adjoining spaces to eliminate cross contamination. IAQ Photocatalytic Virus Filters and final HEPAS on the supply air were also provided. Electrical Research and coordination with lab owner in development of lab tool matrix, In depth analysis of existing electrical service, metering of existing loads, in order to determine the best power source for new lab and its associated HVAC equipment. Also reviewed the backup power requirements and sizing UPS and generator requirements.

Plumbing provided required eye wash system and fixtures with auto faucets. Team worked closely with Owner, Contractor, Vendors & City Planning to achieve TCO for pilot lab in 14 days (design and construction).

L I F E S C I E N C E S

NIAGARA BOTTL ING, LLC

Diamond Bar, CA

Type: R&D Laboratory Size: 382,000 SF

Niagara Bottling, LLC is a family-owned manufacturer of bottled water and soft drinks based in Ontario, California. They produce private label bottled water for a number of companies including Wal-Mart and Costco. As of 2017 Niagara was the largest supplier of private label bottled water in America. Niagara looked towards creating a unique experience for their staff at their new Corporate Headquarters Campus. The scope of work comprised of a core and shell renovation and simultaneous TI of Bldg. 1 (182,000SF), R&D and QA Lab in Bldg. 2 (20,000 SF), site improvements (80,000 SF), 500kW Campus E-Power System and lighting, power and EV charging renovations to a (176,000 SF) parking structure. The Lab comprised of Analytical Rooms, Micro Rooms, Q/A Lab, Sample Storage Rooms, Cold Storage Rooms, R&D Lab and office space. The main office building included a full-service staff cafeteria with waste composting system, Executive Offices, Private offices, Tasting Lounge/Kitchen, Conference rooms, Open Office Space, 3 Story main reception lobby, flex spaces, games rooms, (6) IDF rooms and a Main Server/MDF room.

L I F E S C I E N C E S

TERASAKI RESEARCH GROUP

West Los Angeles, CA

Type: Vivarium suite

AlfaTech is providing engineering design services for the expansion to an existing facility to create a new Vivarium suite within an animal research facility. The project included autoclave cage vivarium cage washers, bio-safety cabinets, procedure rooms, animal handling areas, Rheometer. The facility was designed in accordance with the AAALAC guidelines.

L I F E S C I E N C E S

SOKA UNIVERS ITY OF AMERICA

Aliso Viejo, CA

Type: Campus Expansion, Labs Size: 200,000 SF

AlfaTech is providing mechanical, electrical, and plumbing design services for this university campus expansion project located near Irvine, CA. The Engineering / Science / Lab / Admin Building will be 4 stories and approximately 100,000 SF with classrooms, administrative offices, and wet and dry labs. The Resident Housing facility will be 4 stories and comprised of approximately 75 to 80 rooms.

Both proposed projects will be designed to accommodate a LEED Gold Building Certification, and an exterior architectural design pallet that will respect the current design features, landscaping and cultural aspects of the campus.

L I F E S C I E N C E S

BUCK INSTITUTE STEM CELL RESEARCH LAB

Novato ,CA

Type: Lab, Animal Handling facility Size: 60,000 SF

AlfaTech provided project management, as well as mechanical and electrical engineering services for this project. Systems include the addition of a ground coupled geothermal system, which provides heating and cooling to the new addition and the existing 60,000 SF lab facility. Geothermal ground water at 61 degrees will be used to condition lab fume hood make up air, freeing up 300 tons of cooling from the existing central plant. The additional chilled water tonnage will be used for the new addition. The new geothermal system will provide all cooling & heating for the existing & new 60,000 ft2 lab building, and “no additional tonnage” will be required for the existing central plant. The geothermal system will also save 7,500.000 gallons of water a year from being evaporated via the existing (now decommissioned) cooling towers.

L I F E S C I E N C E S

ABBVIE BIOTHERAPEUTICS (FORMERLY ABBOTT)

Redwood City, CA

Type: Data Center, Campus, Laboratory, Pilot Plant Size: 400,000 SF with central Data Center

AlfaTech was selected as a turnkey firm to design and build Abbott's 400,000 SF new headquarters campus. The facility now houses an Abbott spinoff company called AbbVie. This project includes a 4,000 SF raised floor data center, tenant improvement of offices, along with laboratory facilities, and vivarium (animal care facility). A pilot plant (cell culture and purification) was built on the first floor along with new laboratory facilities, offices, and service yard. AlfaTech was fully responsibly for programming, design and construction of this state-of-the-art campus for which the budget and schedule was guaranteed as a part of our highly successful single-source project delivery method.

L I F E S C I E N C E S

STANFORD UNIVERS ITY CLARK CENTER R&D FACI L ITY

Palo Alto, CA

Type: R&D Laboratory Size: 200,000 SF

This 200,000 SF project is a multi-story building on the Stanford University campus dedicated to biotechnology research and development. The firm was responsible for the design of the HVAC, fume exhaust, building automation, and peer review of the plumbing/process piping systems.

L I F E S C I E N C E S

ALZA

Various Bay Area Sites

Type: Laboratories, cGMP Manufacturing, Vivarium, Office, Pilot Plant Size: 1, 000,000+ SF

Sampling of Projects:

Vacaville cGMP Facilities: • Original Manufacturing Building • Aqueous Tablet Coater • Fluid Bed Dryer • High Shear Granulation • Pharmaceutical Processing Area • Tablet Coating Process • Methylene Chloride Distribution Mountain View Facilities: • Buildings M2 & M3 Biocenter • M1 Pilot Plant & Research Center

Palo Alto Facility: • Buildings M8 & M9 • Underground Tanks

AlfaTech and AlfaTech team members have provided design services for various Bay Area sites listed above.

L I F E S C I E N C E S

GENENTECH

South San Francisco, CA

Type: Office, Laboratory, cGMP Manufacturing Size: 100,000 SF

AlfaTech provided a new $1.1 million, 2-story facility for animal research labs and support areas. The mechanical design features double-duct, double-fan, constant volume mixing boxes with HEPA filtration. In addition, the firm provided full facility design services for Genentech’s Vacaville campus under a Master Services Agreement. This work encompasses office space, laboratory and cGMP manufacturing.

GENENTECH* South San Francisco, CA

Type: R&D Laboratory

Small Portfolio Program ($10 mm and less construction value). Supported Genentech’s Small Project Portfolio program for the pharmaceutical research and manufacturing company’s South San Francisco Campus. Provided Architecture and Engineering planning, design and construction support for a wide variety of facility projects including research labs, GMP cold room upgrades, building condition assessment and upgrades, waste stream compliance and utility systems. Utility systems include electrical infrastructure, steam, compressed air, exhaust, fire suppression, domestic water, sanitary sewer, chilled water and plant gases

* Completed by AlfaTech principal during previous employment

L I F E S C I E N C E S

SANTA CLARA COUNTY OFF ICE OF EDUCATION

San Jose, CA

AlfaTech provided an electrical study for the Santa Clara County Office of Education office complex at 1290 Ridder Park Drive. The study evaluated the facilities electrical system for installation of an emergency power source to back up the buildings electrical service. Different sources were evaluated including various types of generators, solar, wind and fuel cells. Also evaluated were backup of the entire electrical service as well as separating only critical portions of the building for backup.

L I F E S C I E N C E S

GI LEAD SCIENCES

Foster City, CA

Type: Office, Laboratory, cGMP Manufacturing, Pilot Plant, Campus Size: 500,000 SF

AlfaTech provided MEP and telecommunications design for Gilead’s campus consisting of 16 buildings including administrative and private offices, pharmaceutical development processing suites, pilot plants and cGMP therapeutic manufacturing / production areas.

New Systems include: • Process Vacuum System • Nitrogen System • Process Compressed Air System • Cooling System • Dust Collection System

• Exhaust System • System Controls

• Air Shower System • USP Water System • RO/DI Water System • Domestic Water System • N2 Gas System

• Process Waste System • Building Service System • Emergency Power System • Distribution System • Class II Hazardous Locations (Granulation and Drying, Milling and Blending, Tablet Coating, Tablet Compression, Weigh Room)

The firm also provided MEP engineering design services for Gilead’s 35,000 SF pilot plant on the Foster City campus as part of a previous project.

L I F E S C I E N C E S

GENENCOR

Palo Alto, CA

Type: Offices, R&D Laboratory, Pilot Plant Size: 77,500+ SF

This International Technology Center facility combines basic research, pilot plant development, and robotics under one roof. This cGMP project required complete equipment layout, installation design for a pre-manufactured fermentation skid, tank design, and design of three automated 1,500-liter recovery vessels.

L I F E S C I E N C E S

BIOMARIN PHARMACEUTICAL GALL I EAST EXPANS ION (BGEX)

Novato, CA

Type: cGMP Manufacturing Size: 20,000 SF

AlfaTech’s services included management oversight of facilities operations for the manufacturing plant during facility validation. Scope included management of standard operating procedures, spare parts, training of new systems, turnover of systems and facility from contractor to BioMarin and plant engineering services.

BIOMARIN PHARMACEUTICAL* 95 Digital East Laboratory Build-out, Novato, CA

Type: R&D Laboratory

Engineering Design of HVAC, process systems and piping including process cooling water (PCW), clean in place (CIP) systems, deionized water (DI), water for injection (WFI), clean dry air (CDA) and plumbing for build out of shell space to new R&D laboratories.

BIOMARIN PHARMACEUTICAL* Novato, CA

BioMarin executed a utility yard expansion to accommodate additional capacity for lab and manufacturing facilities. The project included specification and conceptual design for addition of a 400-ton chiller to an existing 1000-ton system and 7,000 lb steam boiler to an existing 125 psig plant steam system. The scope also included design of a new enclosed two-story plant utility yard structure with architectural finishes to match the existing building. Challenges included design of new distribution piping to connect new equipment to the existing chilled water and plant steam systems, accommodation of existing equipment including emergency generator and water treatment systems as well as the facility’s loading dock.

* Completed by AlfaTech principal during previous employment

L I F E S C I E N C E S

BAYER HEALTHCARE

*BAYER HEALTHCARE B14 HVAC Upgrade, Berkeley, CA

M C GUFF PHARMACEUTICAL*

Berkeley, CA

Compounding & Filling (503a &503b) Facility Master Plan Santa Anna, CA

Type: Manufacturing Plant Size: 40,000 SF

The goal of this project was to improve occupant comfort and the energy profile of the nearly 100-year-old Building B14 which was being used by research team for critical future drug products. Project challenges included very limited capital available and architectural constraints of a building constructed before HVAC systems were invented such as low ceilings, and no interstitial space. The project team the Target Costing methodology to prioritize the design features in order to stay within budget as a result of early collaboration between the design team, the contractor, the site facility team and the end user. Project features included replacement of existing air handlers, replacement of windows to reduce heat gain and careful HVAC zoning within the space. The project required detailed implementation planning as the project was installed over several budget years.

Responsible for Master Planning, Options Development, Programming, and Conceptual Design for two separate facilities, 503a &503b. On a Greenfield 80,000 SF & 60,000 SF

AlfaTech was selected to perform design construction management services for the replacement and upgrade of the B55 WFI system. The state-of-the- art replacement WFI system consisted of a single HWFI loop with multiple POU heat exchangers. WFI temperatures at the POUs were controlled using HMI panels. The firm scope of work included: interviews with the users to determine WFI consumption; production of complete WFI design-built and demo bid packages; procurement of owner-furnished components; selection of a design-built contractor; and management of the final design and construction effort.

XOMA THERAPEUTICS Berkeley, CA

Type: cGMP Warehouse, Manufacturing, Research, Pilot Plant Size: 8,000 SF and 10,000 SF

For the Pilot Plant, the project includes conversion of the X-5 pilot plant to a combination of manufacturing and research. Modifications were made to the existing facility, bringing it to current ADA standards, and generally “state-of- the-art” status. For the cGMP warehouse facility, the firm provided full design services which entailed the renovation of an existing facility along with validation support and construction management. The warehouse concept entailed the renovation of an existing facility along with validation support.

THE JACKSON LABORATORY WEST West Sacramento, CA

BAYER HEALTHCARE* Various Projects, Berkeley, CA

Type: R&D Laboratory, Vivarium Size: 91,000 SF

This project involved the relocation of Bayer’s BioAnalytics lab necessitated by the planned demolition of the aging building housing the original lab. The project included redesign of the lab layout to improve workflow and accommodate lab analytical equipment and sample storage freezers, design of gas utilities, wet utilities and waste, electrical power and lighting, cabinetry and architectural finishes.

AlfaTech provided MEP design services for interior improvements to an existing tilt-up concrete warehouse, as well as an expansion into an existing facility. The new use of this space includes West Coast regional offices, animal vivarium, wash/sterilization facilities, various research laboratories, animal shipping/staging/support spaces, mechanical yard, and parking .

XOMA THERAPEUTICS Berkeley, CA

Type: GMP & cGMP Fermentation Suite Size: 5,000 SF and 12,000 SF

NEKTAR THERAPEUTICS San Carlos, CA

For the 5,000 SF Fermentation Suite, AlfaTech provided full design and construction management for its GMP new 2,000 liter fermentation suite along with validation support. Design for the 12,000 SF Suite provided a new cGMP fermentation suite consisting of 50 L, 130L, 500L, 2750L, and 12,000L fermenters. These were fully automated with CIP and SIP capability. In addition, a number of media preparation and purification vessels were specified.

BBRAUN* Site Master Planning, Irvine, CA

Type: Laboratory, Office, Manufacturing Size: 4,000 SF

Responsible for the Site Master Planning Options development and the Facility Planning, Evaluation of criteria and constraints, Developing Options for Steering committee selection. Projected $300 million project

AlfaTech provided design services for the consolidation of the central data center, which will occupy approximately 4,000 SF in a currently unoccupied space for Building 3.

* Completed by AlfaTech principal during previous employment

L I F E S C I E N C E S

OREAD

JRH BIOSCIENCES

AMGEN BUI LDINGS 31 AND 42

Palo Alto, CA

Woodland, CA

Thousand Oaks, CA

Type: Laboratory & Manufacturing Size: Robotics Lab, 1,000 SF, Chemistry Lab, 10,000 SF Facilities:

Type: Manufacturing Plant, R&D Laboratory Size: 30,000 SF

Type: cGMP Manufacturing, Office Size: Building 31, 10,000 SF; Building 42, 15,000 SF

• Chemistry Lab • Robotics Lab • WFI/USP Water System

This facility produces media for cell metabolism studies and growth kinetics. It is also used for the research, development and manufacture of proprietary client products. Process piping included a WFI system with a high temperature (85°C) and ambient (25°C) loop and all necessary controls; a clean steam and plant system complete with boiler feed water pump system and blow down cooler; R.O. piping loop and system; process cooling water system with fluid cooler and chilled water heat exchanger; and process gases.

Amgen is a global biotechnology company that discovers, develops, manufactures and markets cost-effective human therapeutics based on advances in cellular and molecular biology. A large-scale dispensing suite was added to Building 31, and Building 42 was a new cGMP raw material receiving facility. On Building 31, AlfaTech provided mechanical, electrical, plumbing, support utility design, specifications, and specialized equipment sourcing for construction of cGMP raw material dispensing suites within an existing warehouse and distribution facility. Building 42 was programmed and designed for cGMP raw material receiving and support for Building 23, a clinical trial manufacturing facility. Process engineering design included liquid caustic solution receiving, storage and transfer systems, and fresh and waste glycerol streams storage and transfer systems.

Oread is a contract provider of comprehensive contract drug development, clinical trial support, finished product manufacturing and packaging, and regulatory support for the pharmaceutical industry. AT provided full engineering services for a robotics dissolution laboratory and the installation of a new formulation chemistry facility with a cGMP WFI system (1,000- gallon storage capacity). Extensive fume hoods contain MRI lab system and sterilizer. AT worked closely with the client during the programming phase and to make sure that the robotics facility, which features a robotically-controlled vial-fill system, would be validatable. The firm also managed the preparation of mechanical, electrical, plumbing, and process designs to meet city permit deadlines.

ARADIGM Hayward, CA

Type: cGMP Pilot Manufacturing Plant Size: 20,000 SF

Aradigm is engaged in the development of novel pulmonary drug delivery systems designed to enhance the delivery and effectiveness of a number of existing and development stage drugs and reduce the need for injectable drug therapy. Clinical trial Phase III quantities of three new products for inhalation therapy will be produced at the new full-scale cGMP clinical and manufacturing facility. AlfaTech also provided services at Aradigm’s 30,000 SF production facility. The project has extensive clean rooms, including Class 100 laminar flow processing areas; a WFI generation and distribution system; and high purity gas distribution.

BRI STOL -MYERS SQUIBB* Redwood City, CA

SLAC NATIONAL ACCELERATOR LABORATORY Palo Alto, CA

This project consisted of replacement of an aging and inefficient chilled water system serving Autoclaves in the facility’s vivarium. A key project challenge included addressing a widely variable load. The chiller was specified with three compressors to allow efficient coverage of the loads.

Type: FEH Hutches 4, 5, &6

AlfaTech provided a feasibility study for the FEH Hutches 4, 5 and 6 project to define alternate system solutions for the HVAC design. The project was in the final design phase using a single unit air handling system. The distribution system was going to occupy space that the owner wanted to reserve for future use. We provided a conceptual design study to evaluate how much space could be saved using a different system. The study included pros and cons of each system, sketches for cost estimating and peer review of existing design documents.

* Completed by AlfaTech principal during previous employment

L I F E S C I E N C E S

VIVUS

NOVARTI S (CHIRON)*

JANSSEN PHARMACEUTICALS*

Lakewood, NJ

Vacaville, CA

Vacaville, CA

Type: Laboratory, Manufacturing Size: 80,000 SF

Type: VMF OLWX Project Manufacturing Facility Expansion Size: 17,000 SF, two-story building

Numerous upgrade and expansion projects were executed throughout all aspects of the facility including labs, manufacturing process and HVAC systems and building utility upgrades, manufacturing clean room projects, site infrastructure and utilities and administrative tenant improvements. Projects included: • Multi-year plantwide HVAC system renovation and replacement to modernize the plant’s clean room HVAC systems and to meet cGMP requirements. • Process Dust Collection System collecting hazardous dust produced pharmaceutical product manufacturing. • Manufacturing Suite projects to accommodate new products and processes including suite workflow layout, utility system design (electrical, O2, AOF, N2, chilled water, clean steam, etc.), waste streams, Architectural improvements. • Regenerative Thermal Oxidizer • Manufacturing Equipment Safety Upgrades to meet J&J Corporate safety standards • Raw Materials Warehousing and Lab • 1MW Solar Farm Condition Assessment and Upgrades • Manufacturing Washrooms • QC Labs

AlfaTech acted as the owner’s principal engineer for design of a facility that expanded their capacity to formulate and produce a new drug and drug delivery system. The scope of work involved HVAC, process utilities, R.O./D.I. and hot USP water systems, production room layout, and general engineering support. AT also worked closely with the validating agency to provide a complete turnover package.

Full Civil and MEP design services for a 17,000 SF two-story building expansion. The expansion included private offices, open office areas, meeting, conference and storage rooms, corridors, stairs, restrooms, elevator, QA/QC engineering document storage room, QC and raw materials laboratories and process equipment storage, in the following cGMP areas: weigh/dispense room, quarantined and released materials.

BAXTER HEALTHCARE Hayward, CA

NOVARTI S (CHIRON)* San Carlos, CA

Type: cGMP Laboratory

This Hyland Division Laboratory renovation project involved a complete remodel and relocation of the biotechnology process rooms. Construction documents and validation for a cGMP upgrade of the existing facility were also required.

Engineering Design for multiple facility projects including: • Temperature Control for CSD-1 Dryer • Laboratory Humidification System Replacement • Site Energy Manager (Staff Augmentation) • Sitewide Electrical Power Study and Maintenance Plan • Niro-2 Exhaust Modifications (Design/Build Project Delivery)

COLLAGEN AESTHETICS INC. Fremont, CA

• Code Studies • Data Center

NOVARTI S (CHIRON)* Emeryville, CA

Type: Manufacturing Plant Size: 12,000 SF Facilities: • Bulk Processing Area Addition • Office Space Tenant Improvements • Warehouse and Office Space

PAR, FAIRBANK OSD* Facility Master Plan, Irvine, CA

Architecture and Engineering Design for multiple facility projects including: • Site Wide Energy Efficiency Study • Building 4 Lab Tenant Improvements • Robotics Lab Tenant Improvements • Building 4 Executive Conference Center • Building G&T Chilled Water System Upgrades Concept Design

Responsible for Master Planning, Options Development, Programming, and Conceptual Design of the facility. For an existing 90,000 SF OSD Facility that includes manufacturing, QC lab, lab support, warehousing and administrative functions

Collagen Aesthetics Inc. develops, manufactures, and markets on a worldwide basis high quality biocompatible products for the treatment of defective, diseased, traumatized or aging human tissues. This project modified existing Class 100 – 10,000 spaces for laminar flow filling suites for new product manufacturing. The firm maintains Collagen’s library of as-built drawings to support ISO 9001 certification.

* Completed by AlfaTech principal during previous employment

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