AlfaTech Big Book

SOLUTIONS FOR THE LIFE SCIENCES

INNOVATIVE IDEAS | INTEGRATED SOLUTIONS | SUSTAINABLE PARTNERS

01

OVERVIEW / FIRM Profile

02

LIFE SCIENCES Team Leads

03

LIFE SCIENCES Capabilities

04

RELEVANT PROJECTS

Life Sciences

Higher Education

Mission Critical

OVERVIEW 01

Firm Profile

F I RM P R O F I L E

AlfaTech has built its reputation on providing the most innovative and sustainable engineering solutions from master planning through construction administration. Our presence is not only in the continental United States, but internationally as well. Our clients include numerous large multi-national firms, many ongoing clients we’ve been serving for years. We strive to provide intelligent and innovative strategies starting with project inception, in order to provide maximum benefit to our clients during the entire development process whether it be new high-rise projects, mixed use projects or revitalization of existing communities. Our team provides the most appropriate engineering design solutions which are highly efficient and cost effective, and promotes the greatest possible return on investment for our clients. Our goal is to build the most dynamic relationships, be attentive to the needs of our clients and partners, and be true team players. With this mindset, we’ve built a stellar list of clients.

AbbVie Biotherapeutics

Alza

eBay

UNITED STATES San Francisco San Jose Los Angeles Atlanta

INTERNATIONAL Europe Asia Middle East Latin America Africa

AlfaTech RSBG Infrastructure Dorsch Gruppe Qvest Media SecurView

Additional Resources Through Our Sister Companies

100+ locations | 55+ countries | 3,600+ staff

F I RM P R O F I L E

F I RM P R O F I L E

OUR CORE MARKETS

AlfaTech has decades of experience with clients throughout the United States and across the globe. Our projects range from high-end tenant improvements to new, ground up projects and large corporate campuses. Our portfolio continues to grow with new and exciting clients who are Fortune 500 companies, successful start-ups and professional services firms. We provide full design, design assist and design/build project delivery methods, and our experience covers core and shell facilities, tenant improvement projects, upgrades, and restacks. We provide expertise in a number of markets, including:

Life Sciences Healthcare

Advanced Technology Corporate TI + Campus Mission Critical Higher Education K-12 Education

S E R V I C E S

MECHANICAL ENGINEERING DESIGN HVAC

ARCHITECTURAL LIGHTING DESIGN Lighting and Lighting Controls Lighting Calculations

COMMISSIONING | ENERGY SOLUTIONS Early Quantifiable Energy Study Incentives

Heating Systems Water and Gas Cooling Systems / Chilled Water Dehumidification Systems Contamination Sensitive Areas Industrial Hygiene Systems Low Tolerance Temp Control Title 24 Analysis and Design Heat Recovery Systems Central Utility Plants Air Handlers HVAC System Controls PLC Programming Fire Protection and Plumbing

Customized ROI Calculations Sustainable Lighting Design

Energy Star® Assessments Retro-commissioning (RCx) Monitoring Brand Continuous Commissioning (MBCCx) ASHRAE Level 1, 2 and 3 Energy Audits Measurement and Verification (M&V) of installed projects Energy Modeling Net Zero Energy Budgeting HVAC/Chilled Water Plant Optimization

Energy Savings Analysis Custom Lighting Fixtures Design for finishes, fabrics and light sources

TECHNOLOGY DESIGN Low Voltage Design Security Design Audio Visual Design Wireless Design & Modeling

PROCESS Industrial Waste Collection Acid Neutralization Bio-Kill Waste System Process Waste Containment Ultra pure De-ionized Water Systems USP Water WFI Specialty Chemicals Chemical Storage

Strategic Consulting Project Management Relocation & Migration

ELECTRICAL ENGINEERING DESIGN Power Systems

Emergency & Standby Power Lighting and Lighting Controls Security Systems 24 / 7 Power Systems (UPS) Power Monitoring Systems Toxic Gas Monitoring Graphic Control and Alarm Panels Grounding and Bonding

SUSTAINABILITY Sustainability Planning (Organizational and Infrastructural) LEED / Green Building Consulting Masterplanning Life Cycle Cost Assessment Occupant Wellness and Comfort

Lab and Special Gas Systems Ultra High Purity Gas Piping

Bulk & Specialty Gases Toxic Materials Handling Code Compliance Process Distribution Piping Process Cooling Water Medical Gas Medical Vacuum Waste Anesthetic Gas Disposal system (WAGD)

Energy Management Energy Conservation Fire Alarm Systems Public Address Systems Plug Loads Control

Façade Engineering CFD / Wind Studies Wind Studies Thermal Stratification Studies Energy Concept Studies

Dental Vacuum System Dental Water System

S E R V I C E S

C L I E N T S

JDS Uniphase Corporation John Muir Medical Center Johnson & Johnson Johnson Controls JP Morgan Chase JRH Biosciences Juniper Networks Junipero Serra High School Kaiser HealthConnect Kaiser Permanente Kasowitz, Benson, et al

Novell Novellus Systems NVIDIA Ohlone Community College OptiSolar Oracle Orchard Properties Oread Pacific Bell PDL BioPharma PG&E Panattoni Europe Pfizer Philips Semiconductor Pitney Bowes Polycom Port of San Francisco Presidio Trust Price Waterhouse Coopers Qualcomm Queens Medical Center Rambus Raytheon Company

Scripps Memorial Hospital Sequoia Hospital CHW Sequoia UHSD Siemens SLAC National Accelerator Laboratory Solectron Corporation Sony America Spansion Sprint SRI International (Stanford Research) Stanford Healthcare & Clinics Stanford University Stanford University Medical Center

365 Main 3M Company AARP Abbott Biotherapeutics Abbott Laboratories Abbvie Abgenix Abt Associates ACCO Engineered Systems Adaptec AOC Adobe Systems Advanced Micro Devices Advantest America Advent Software Aetna Affymetrix Agilent Technologies Agnes Medical Center Akamai Technologies Alcoa Allen, Matkins, et al Alliance Bernstein, LLP Alta Bates Health System Altera Corporation Alum Rock School District Alza Amazon/Lab 126 Ambiance Associates Ambience Interiors Amdocs American Express Company Amgen Amprius

Bingham McCutchen, LLP Bio-Rad Laboratories BioGenex Biomarin Pharmaceutical BioMed Realty Trust Bloom Energy BMC Software Booz Allen Hamilton Inc

County of Sacramento County of San Mateo County of Santa Clara Credence CSAA

CSU Northridge Cupertino USD Daughters of Charity Health Dell Deloitte Consulting Digital Realty Trust Dignity Health Dominican Hospital Dropbox Dupont East Side Union HSD eBay Eil Lilly & Company Elsevier Inc Emirates National Oil Empire State Development Equinix Equis Corporation Ericsson Ernst & Young LLP Exelixis Ferrari Maserati of Silicon Valley Fidelity Investments Fireman’s Fund Insurance First Franklin Financial Corp Flextronics Foundry Networks Franklin Templeton Investments Genencor Genentech General Dynamics General Electric Genzyme Corporation Gilead Sciences Goldman Sachs Good Samaritan Hospital GSA Harbor UCLA Medical Center Hayward USD

Boston Properties Boston Scientific Bradford Schools Bristol-Myers Squibb Broadcom Broadreach Capital Partners Brocade Buck Institute Stem Cell Research Lab Cadence Design Systems Cal Pacific Med Center California Department of Mental Health CarrAmerica Development Cedars-Sinai Medical Center Chabot Las Positas CCD Charles Schwab Chevron Children’s Hospital, Los Angeles County Children’s Hospital, Oakland Children’s Hospital, Orange County Children’s Hospital, San Antonio Chinese Hospital Cisco Systems Citigroup Realty Services

Kimpton Hotels KLA-Tencor Corp La Clinica De La Raza

Stion Corporation Stryker Endoscopy Stubhub Sun Microsystems SunPower Sutter Health

Lam Research Laney College

Lawrence Berkeley Lab Letterman Digital Arts Levi Strauss & Company Linear Technology LinkedIn Lockheed Martin Corp Logitech Longs Drug Stores Los Gatos Saratoga HSD Lumentum Marriott International Martin Luther King, Jr. Community Hospital Marvell Semiconductor Maxim McKesson Medarex Menlo Park City School District Mercy Southwest Hospital Microsoft

Sybase Inc Symantec Synopsys Inc Sysorex T-Mobile Tencent Tesla Motors The Gap Twitter Uber UC Berkeley UC Davis UC Davis Medical Center UC San Francisco

Regional Medical Center Riverbed Technologies Robert Half International Roche Bioscience Ross Stores Sacramento Municipal Utility District Safeway Saint Francis Memorial Hospital Saint Joseph Hospital Saint Louise Regional Hospital Saint Mary’s Hospital Samaritan Medical Center Samsung San Francisco City Hall San Francisco International Airport San Francisco USD San Jose Medical Center San Jose Redevelopment Agency San Jose State University San Jose USD San Mateo CCCD San Mateo County Office of Education Sandia Laboratories Santa Clara County Health Dept. Santa Clara County Library Santa Clara County Office of Education Santa Clara USD Santa Clara University

City of Cupertino City of Foster City

UC Santa Cruz UC Los Angeles UCLA Outpatient Surgery/Oncology Center UCSF Mission Bay Medical Center Ultratech University of Colorado Hospital

City of Fremont City of Monterey City of Mountain View City of Newark City of Oakland City of Palo Alto City of Sacramento City of San Jose

Amstein + Walthert Anderson Architects Anixter Applied Dynamics Applied Materials Aradigm AT&T Park Clinic Atmel Corp Autodesk Avaya Avid Technology Avidex BAE Systems Bank of America Banuazizi Architects Bayer Healthcare Bechtel Corporation Bell, Rosenberg, et al Berryessa USD

Mills/Peninsula Hospital Mission Oaks Hospital Molecular Devices Monterey Peninsula College Morgan Hill USD Morgan Stanley Morrison & Foerster Motorola Mountain View School District MW Zander NASA-Ames National Semiconductor Network Appliance Nokia Nortel Networks North Bay Medical Center Northrop Grumman Novartis

University of Nevada University of Virginia URS Valley Medical Center Verisign Verity Health Verizon Communications Veteran’s Administration Visa International Vivus VMware Wachovia Bank

City of San Mateo City of Santa Clara City of Saratoga City of South San Francisco City of Sunnyvale College of Contra Costa College of Marin Colliers International Computer Associates Int’l Compuware CoreSite County of Monterey

Hewlett Packard Highland Hospital Hitachi America IBM Impax Laboratories Informatica Corporation Intel InterMune Intuit J&W Scientific

SAP Labs LLC Saratoga USD Savvis

Washington Hospital Xoma Therapeutics Yahoo

02 LIFE SCIENCES

Team Leads

L I F E S C I E N C E S T E AM L E A D S

ABOUT THE TEAM

AlfaTech has assembled a highly qualified team of professionals to serve our Life Science clients. The staff shown on these pages comprise our lead professionals overseeing staff in their respective disciplines. Each lead individual brings extensive experience providing planning, analysis, design and construction administration services required to execute projects in the challenging and exacting environments of Life Sciences facilities whether they be laboratories, GMP manufacturing, utility systems, office space or campus infrastructure. With our in-house staff and strategic partners, AlfaTech provides solutions throughout the entire life cycle of our clients’ facilities including site selection, planning and design, commissioning, validation and startup. Our experts support ongoing operations including FDA Inspection preparation and recommissioning. Our team is dedicated to providing the highest quality services available in our industry.

TERRY STELTER Senior Principal, Life Sciences

Terry Stelter is the Senior Principal-in-Charge of the AlfaTech Consulting Engineer’s Life Sciences business unit. He has over 20 years of experience with multi-disciplined teams for many high-profile clients in the Life Sciences industry. Terry’s Life Science experience includes projects in R&D laboratories, pharmaceutical manufacturing, commercial buildings for life sciences clients, and campus infrastructure. He is well versed in cGMP requirements and design and construction standards required for FDA compliance. He has extensive experience in the pharmaceutical, biotech and medical device industries, with notable clients such as Genentech, Bayer, Johnson and Johnson, and Novartis.

HARV VIJ Principal Process Engineer

Harv has over 20 years of experience in design, commissioning, project engineering / management and validation support of manufacturing systems and cGMP facilities design and construction. His experience consists of projects in pharmaceutical manufacturing, R&D laboratories, biotechnology and educational facilities. Harv is experienced in cGMP facility design, commissioning, critical utilities systems such as WFI, clean steam, CIP and process gases.

Technical Leadership is supported by over 140 employees in the AlfaTech design group.

L I F E S C I E N C E S T E AM L E A D S

MARK FISHER, PE, LEED AP Lead E lectrical Engineer

BILL HARRISON, RA Project Manager

Mark has over 30 years of experience in the design and construction of commercial offices, mission critical, clean rooms, manufacturing, educational and others. He is well versed in the preparation of programming and master plans, feasibility studies, building evaluations, and coordination studies. As well as all types of lighting and electrical design including low/medium voltage power distribution, lighting, fire alarm, security and low voltage technology systems. Mark has been lead engineer on numerous LEED certified projects, three LEED Platinum.

Bill is an experienced project and client manager with over twenty years of experience managing multi-discipline design projects and observing construction for multiple advanced technology, biopharmaceutical and hospital clients. His extensive experience includes architectural, mechanical, process piping, plumbing design, as well as management and coordination of multidiscipline design teams from conceptual design through construction close-out. He has served as project manager, project architect and designer on a variety of projects. His services include master planning, space planning, contract documents, construction administration and quality control.

KEN KAHRS, PE, LEED AP Lead Mechan ical Engineer

JOSE GONZALEZ Lead E lectrical Engineer

Ken has over 25 years of experience in HVAC, process piping and plumbing design. Mechanical design experience includes a wide range of projects for pharmaceutical and biotechnology laboratories, vivariums, health care facilities, clean rooms, data centers, research labs, site utility piping, central plant design, and campus utility infrastructures.

Jose has over 40 years of design and construction management experience, responsible for the overall design of electrical systems of major projects from conceptual design to delivery that includes electrical and lighting systems for biopharmaceutical, high tech, mission critical/data center, corporate office and educational facilities.

JAY CHOKSHI Principal, Mechan ical Engineer

SHERIF MESSIHA, AIA, NCARB Life Science Lab Planner

Jay has extensive experience as a Principal-in-Charge and as project manager in design of major HVAC engineering efforts for Life Sciences, Mission Critical, Commercial, and Healthcare projects. His background includes design for laboratories, clean rooms, vivariums, pilot plants and commercial manufacturing. With much of his experience being in fast-track design/build, he works closely with architects and contractors to ensure an efficient, cost effective solution. In addition, Jay manages multi-discipline engineering design teams for large scale projects. An expert in energy efficient design, he specializes in post-occupancy commissioning.

Sherif has over 32 years extensive portfolio in designing Life Science Projects and Site Master Planning worldwide in the Pharmaceutical, Biotech, Nutritional, Food and Beverage, and Cosmetic industries. He has developed a six-step interview process that, captures, creates food for thought, documents, gets the client involved, and prepares the documents from Conceptual to signed Detail Design stage.

03 LIFE SCIENCES

Capabilities

L I F E S C I E N C E S

AlfaTech offers a full range of professional engineering services from concept creation to commissioning and validation, including feasibility studies, condition assessments, planning, design, program management and construction period services. Our experienced professionals are expert in cGMP and GLP compliance and understand the difficult decisions Life Science facility owners make every day when choosing between economy and function. Our team has the experience and capabilities to address projects throughout our clients’ facilities from labs to manufacturing or corporate office and campus infrastructure. We have the capacity, experience and business structure that allows us to support a wide range of projects from the small consulting scope to ground-up campus projects.

This combination of resources and skills provides a strong value proposition, predicated on innovative solutions and disciplined cost, quality and schedule management.

STRATEGIC PARTNER SERVICES Architectural Planning and Design Structural Engineering Process Controls Validation Site Civil Engineering Turnkey Clean Process Utilities

SERVICES Process Engineering Lab Planning and Design Master Planning Mechanical Engineering Electrical Engineering Facility Condition Assessment

Site Selection Sustainability

FDA and EU Compliance Consulting Commissioning and Energy Solutions

L I F E S C I E N C E S

GENERAL BUILDING / CAMPUS SYSTEMS AND SPACES Electrical Distribution (480V to Low Voltage Systems) Site Electrical Distribution Backup Generation UPS HVAC Technology Systems (Communication, AV, Security, WIFI) Lighting and Lighting Controls BMS/EMS Tank Farms and Utility Yards

LABORATORIES Clinical GLP QC BSL 1, 2 and 3 Flexible Labs

PLANT AIR SYSTEMS Scrubbers Clean Rooms Room Pressure Profiles and Cascade HEPA Filtration Exhaust Hoods and Dust Collection Explosion Relief

cGMP COMPLIANT MANUFACTURING FACILITIES Pilot Plant Clean Rooms Commercial Manufacturing Process Batching and Campaigning Areas Blending and Mixing Rooms Fill and Finish Wash Room Packaging and Labeling Production Equipment Specification Production Equipment Utility Hookup Isolation Technology Containment Facilities Gowning Rooms Warehouse and Material Handling

PERMITTING AND REGULATORY COMPLIANCE FDA Inspection Readiness Support Air Permitting Support Code Analysis and Building Code Occupancy Issues Building Permit Administration and Support WASTE WATER AND HAZARDOUS WASTE TREATMENT Waste Treatment Process Design Recycling Systems Heavy Metals Removal and Neutralization Reverse Osmosis and Ultra Filtration Solids Removal Systems Biohazard Treatment and Detoxification Incineration

Truck Docks Warehouse Data Centers Corporate Office

PROCESS AND BUILDING UTILITY SYSTEMS WFI

CIP and SIP Clean Steam Process Chilled Water RO/DI CDA Specialty Gases Lab Gases Solvent Systems Central Plants

04

Relevant Projects

LIFE SCIENCES

L I F E S C I E N C E S

ABBVIE BIOTHERAPEUTICS (FORMERLY ABBOTT)

Redwood City, CA

Type: Data Center, Campus Size: 400,000 SF with central Data Center

AlfaTech was selected as a turnkey firm to design and build Abbott's 400,000 SF new headquarters campus. The facility now houses an Abbott spinoff company called AbbVie. This project includes a 4,000 SF raised floor data center, tenant improvement of offices, along with laboratory facilities, and vivarium (animal care facility). A pilot plant (cell culture and purification) was built on the first floor along with new laboratory facilities, offices, and service yard. AlfaTech was fully responsibly for programming, design and construction of this state-of-the-art campus for which the budget and schedule was guaranteed as a part of our highly successful single-source project delivery method.

L I F E S C I E N C E S

GENENTECH

South San Francisco, CA

Type: Laboratory Size: 100,000 SF

AlfaTech provided a new $1.1 million, 2-story facility for animal research labs and support areas. The mechanical design features double-duct, double-fan, constant volume mixing boxes with HEPA filtration. In addition, the firm provided full facility design services for Genentech’s Vacaville campus under a Master Services Agreement. This work encompasses office space, laboratory and cGMP manufacturing.

* GENENTECH South San Francisco, CA

Small Portfolio Program ($10 mm and less construction value). Supported Genentech’s Small Project Portfolio program for the pharmaceutical research and manufacturing company’s South San Francisco Campus. Provided Architecture and Engineering planning, design and construction support for a wide variety of facility projects including research labs, GMP cold room upgrades, building condition assessment and upgrades, waste stream compliance and utility systems. Utility systems include electrical infrastructure, steam, compressed air, exhaust, fire suppression, domestic water, sanitary sewer, chilled water and plant gases

* Completed by AlfaTech principal during previous employment

L I F E S C I E N C E S

BUCK INSTITUTE STEM CELL RESEARCH LAB

Novato ,CA

Type: Lab, Animal Handling facility Size: 60,000 SF

AlfaTech provided project management, as well as mechanical and electrical engineering services for this project. Systems include the addition of a ground coupled geothermal system, which provides heating and cooling to the new addition and the existing 60,000 SF lab facility. Geothermal ground water at 61 degrees will be used to condition lab fume hood make up air, freeing up 300 tons of cooling from the existing central plant. The additional chilled water tonnage will be used for the new addition. The new geothermal system will provide all cooling & heating for the existing & new 60,000 ft2 lab building, and “no additional tonnage” will be required for the existing central plant. The geothermal system will also save 7,500.000 gallons of water a year from being evaporated via the existing (now decommissioned) cooling towers.

L I F E S C I E N C E S

ALZA

Various Bay Area Sites

Type: Laboratories, Manufacturing, Biocenter, Vivarium, Office, Pilot Plant Size: 1,000,000+ SF

Sampling of Projects:

Vacaville cGMP Facilities: • Original Manufacturing Building • Aqueous Tablet Coater • Fluid Bed Dryer • High Shear Granulation • Pharmaceutical Processing Area • Tablet Coating Process • Methylene Chloride Distribution Mountain View Facilities: • Buildings M2 & M3 Biocenter • M1 Pilot Plant & Research Center

Palo Alto Facility: • Buildings M8 & M9 • Underground Tanks

AlfaTech and AlfaTech team members have provided design services for various Bay Area sites listed above.

L I F E S C I E N C E S

GILEAD SCIENCES

Foster City, CA

Type: Laboratory, Office, Manufacturing Size: 500,000 SF

AlfaTech provided MEP and telecommunications design for Gilead’s campus consisting of 16 buildings including administrative and private offices, pharmaceutical development processing suites, pilot plants and cGMP therapeutic manufacturing / production areas.

New Systems include: • Process Vacuum System • Nitrogen System • Process Compressed Air System • Cooling System • Dust Collection System

• Exhaust System • System Controls

• Air Shower System • USP Water System • RO/DI Water System • Domestic Water System • N2 Gas System

• Process Waste System • Building Service System • Emergency Power System • Distribution System • Class II Hazardous Locations (Granulation and Drying, Milling and Blending, Tablet Coating, Tablet Compression, Weigh Room)

The firm also provided MEP engineering design services for Gilead’s 35,000 SF pilot plant on the Foster City campus as part of a previous project.

L I F E S C I E N C E S

GENENCOR

Palo Alto, CA

Type: Laboratory, Offices, Pilot Plant Size: 77,500+ SF

This International Technology Center facility combines basic research, pilot plant development, and robotics under one roof. This cGMP project required complete equipment layout, installation design for a pre-manufactured fermentation skid, tank design, and design of three automated 1,500-liter recovery vessels.

L I F E S C I E N C E S

BIOMARIN PHARMACEUTICAL GALLI EAST EXPANSION (BGEX)

Novato, CA

Type: cGMP Manufacturing Size: 20,000 SF

AlfaTech’s services included management oversight of facilities operations for the manufacturing plant during facility validation. Scope included management of standard operating procedures, spare parts, training of new systems, turnover of systems and facility from contractor to Biomarin and plant engineering services.

*BIOMARIN PHARMACEUTICAL 95 Digital East Laboratory Build-out, Novato, CA

Engineering Design of HVAC, process systems and piping including process cooling water (PCW), clean in place (CIP) systems, deionized water (DI), water for injection (WFI), clean dry air (CDA) and plumbing for build out of shell space to new R&D laboratories.

*BIOMARIN PHARMACEUTICAL Novato, CA

BioMarin executed a utility yard expansion to accommodate additional capacity for lab and manufacturing facilities. The project included specification and conceptual design for addition of a 400-ton chiller to an existing 1000-ton system and 7,000 lb steam boiler to an existing 125 psig plant steam system. The scope also included design of a new enclosed two-story plant utility yard structure with architectural finishes to match the existing building. Challenges included design of new distribution piping to connect new equipment to the existing chilled water and plant steam systems, accommodation of existing equipment including emergency generator and water treatment systems as well as the facility’s loading dock.

* Completed by AlfaTech principal during previous employment

L I F E S C I E N C E S

BAYER HEALTHCARE

*BAYER HEALTHCARE B14 HVAC Upgrade, Berkeley, CA

*M C GUFF PHARMACEUTICALS

Berkeley, CA

Compounding & Filling (503a &503b) Facility Master Plan Santa Anna, CA

Type: Manufacturing Plant Size: 40,000 SF

The goal of this project was to improve occupant comfort and the energy profile of the nearly 100-year-old Building B14 which was being used by research team for critical future drug products. Project challenges included very limited capital available and architectural constraints of a building constructed before HVAC systems were invented such as low ceilings, and no interstitial space. The project team the Target Costing methodology to prioritize the design features in order to stay within budget as a result of early collaboration between the design team, the contractor, the site facility team and the end user. Project features included replacement of existing air handlers, replacement of windows to reduce heat gain and careful HVAC zoning within the space. The project required detailed implementation planning as the project was installed over several budget years.

Responsible for Master Planning, Options Development, Programming, and Conceptual Design for two separate facilities, 503a &503b. On a Greenfield 80,000 SF & 60,000 SF

AlfaTech was selected to perform design construction management services for the replacement and upgrade of the B55 WFI system. The state-of-the- art replacement WFI system consisted of a single HWFI loop with multiple POU heat exchangers. WFI temperatures at the POUs were controlled using HMI panels. The firm scope of work included: interviews with the users to determine WFI consumption; production of complete WFI design-built and demo bid packages; procurement of owner-furnished components; selection of a design-built contractor; and management of the final design and construction effort.

NEKTAR THERAPEUTICS San Carlos, CA

Type: Laboratory, Office, Manufacturing Size: 4,000 SF

AlfaTech provided design services for the consolidation of the central data center, which will occupy approximately 4,000 SF in a currently unoccupied space for Building 3.

THE JACKSON LABORATORY WEST West Sacramento, CA

*BAYER HEALTHCARE Various Projects, Berkeley, CA

Type: R&D Laboratory Size: 91,000 SF

*B. BRAUN Site Master Planning, Irvine, CA

This project involved the relocation of Bayer’s BioAnalytics lab necessitated by the planned demolition of the aging building housing the original lab. The project included redesign of the lab layout to improve workflow and accommodate lab analytical equipment and sample storage freezers, design of gas utilities, wet utilities and waste, electrical power and lighting, cabinetry and architectural finishes.

AlfaTech provided MEP design services for interior improvements to an existing tilt-up concrete warehouse, as well as an expansion into an existing facility. The new use of this space includes West Coast regional offices, animal vivarium, wash/sterilization facilities, various research laboratories, animal shipping/staging/support spaces, mechanical yard, and parking .

Responsible for the Site Master Planning Options development and the Facility Planning, Evaluation of criteria and constraints, Developing Options for Steering committee selection. Projected $300 million project.

* Completed by AlfaTech principal during previous employment

L I F E S C I E N C E S

OREAD

AMGEN BUILDINGS 31 AND 42

*JANSSEN PHARMACEUTICALS

Palo Alto, CA

Thousand Oaks, CA

Vacaville, CA

Type: Laboratory & Manufacturing Size: Robotics Lab, 1,000 SF, Chemistry Lab, 10,000 SF Facilities:

Type: cGMP Manufacturing, Office Size: Building 31, 10,000 SF; Building 42, 15,000 SF

Numerous upgrade and expansion projects were executed throughout all aspects of the facility including labs, manufacturing process and HVAC systems and building utility upgrades, manufacturing clean room projects, site infrastructure and utilities and administrative tenant improvements. Projects included: • Multi-year plantwide HVAC system renovation and replacement to modernize the plant’s clean room HVAC systems and to meet cGMP requirements. • Process Dust Collection System collecting hazardous dust produced pharmaceutical product manufacturing. • Manufacturing Suite projects to accommodate new products and processes including suite workflow layout, utility system design (electrical, O2, AOF, N2, chilled water, clean steam, etc.), waste streams, Architectural improvements. • Regenerative Thermal Oxidizer • Manufacturing Equipment Safety Upgrades to meet J&J Corporate safety standards • Raw Materials Warehousing and Lab • 1MW Solar Farm Condition Assessment and Upgrades • Manufacturing Washrooms • QC Labs

• Chemistry Lab • Robotics Lab • WFI/USP Water System

Amgen is a global biotechnology company that discovers, develops, manufactures and markets cost-effective human therapeutics based on advances in cellular and molecular biology. A large-scale dispensing suite was added to Building 31 and Building 42 was a new cGMP raw material receiving facility. On Building 31, AlfaTech provided mechanical, electrical, plumbing, support utility design, specifications, and specialized equipment sourcing for construction of cGMP raw material dispensing suites within an existing warehouse and distribution facility. Building 42 was programmed and designed for cGMP raw material receiving and support for Building 23, a clinical trial manufacturing facility. Process engineering design included liquid caustic solution receiving, storage and transfer systems, and fresh and waste glycerol streams storage and transfer systems.

Oread is a contract provider of comprehensive contract drug development, clinical trial support, finished product manufacturing and packaging, and regulatory support for the pharmaceutical industry. AT provided full engineering services for a robotics dissolution laboratory and the installation of a new formulation chemistry facility with a cGMP WFI system (1,000- gallon storage capacity). Extensive fume hoods contain MRI lab system and sterilizer. AT worked closely with the client during the programming phase and to make sure that the robotics facility, which features a robotically-controlled vial-fill system, would be validatable. The firm also managed the preparation of mechanical, electrical, plumbing, and process designs to meet city permit deadlines.

*BRISTOL -MEYERS SQUIBB Redwood City, CA

This project consisted of replacement of an aging and inefficient chilled water system serving Autoclaves in the facility’s vivarium. A key project challenge included addressing a widely variable load. The chiller was specified with three compressors to allow efficient coverage of the loads.

• Code Studies • Data Center

* Completed by AlfaTech principal during previous employment

L I F E S C I E N C E S

BAXTER HEALTHCARE

*NOVARTIS (CHIRON)

*NOVARTIS (CHIRON)

. Hayward, CA

Vacaville, CA

Emeryville, CA

Type: Laboratory

Type : VMF OLWX Project Manufacturing Facility Expansion Size: 17,000 SF, two-story building

Architecture and Engineering Design for multiple facility projects including: • Site Wide Energy Efficiency Study • Building 4 Lab Tenant Improvements • Robotics Lab Tenant Improvements • Building 4 Executive Conference Center • Building G&T Chilled Water System Upgrades Concept Design

This Hyland Division Laboratory renovation project involved a complete remodel and relocation of the biotechnology process rooms. Construction documents and validation for a cGMP upgrade of the existing facility were also required.

Full Civil and MEP design services for a 17,000 SF two-story building expansion. The expansion included private offices, open office areas, meeting, conference and storage rooms, corridors, stairs, restrooms, elevator, QA/QC engineering document storage room, QC and raw materials laboratories and process equipment storage, in the following cGMP areas: weigh/dispense room, quarantined and released materials.

COLLAGEN AESTHETICS INC. Fremont, CA

SLAC NATIONAL ACCELERATOR LABORATORY Palo Alto, CA

Type: Manufacturing Plant Size: 12,000 SF Facilities: • Bulk Processing Area Addition • Office Space Tenant Improvements • Warehouse and Office Space

*NOVARTIS (CHIRON) San Carlos, CA

Type: FEH Hutches 4, 5, &6

AlfaTech provided a feasibility study for the FEH Hutches 4, 5 and 6 project to define alternate system solutions for the HVAC design. The project was in the final design phase using a single unit air handling system. The distribution system was going to occupy space that the owner wanted to reserve for future use. We provided a conceptual design study to evaluate how much space could be saved using a different system. The study included pros and cons of each system, sketches for cost estimating and peer review of existing design documents.

Engineering Design for multiple facility projects including: • Temperature Control for CSD-1 Dryer • Laboratory Humidification System Replacement • Site Energy Manager (Staff Augmentation) • Sitewide Electrical Power Study and Maintenance Plan • Niro-2 Exhaust Modifications (Design/Build Project Delivery)

Collagen Aesthetics Inc. develops, manufactures, and markets on a worldwide basis high quality biocompatible products for the treatment of defective, diseased, traumatized or aging human tissues. This project modified existing Class 100 – 10,000 spaces for laminar flow filling suites for new product manufacturing. The firm maintains Collagen’s library of as-built drawings to support ISO 9001 certification.

* Completed by AlfaTech principal during previous employment

HIGHER EDUCATION

H I G H E R E D U C AT I O N

OHLONE COMMUNITY COLLEGE – LEED-NC PLATINUM

Newark, CA

Type : New Construction Size : 130,000 SF

AlfaTech provided mechanical and electrical engineering master planning and full design services for the new, 130,000 gross square foot, 81-acre, multi-building campus in Newark.

Our energy efficient design included the use of solar energy with roof-mounted PowerGuard 450kV photovoltaic panels, a large geothermal loop system for heating and air conditioning, highly efficient plumbing fixtures and an enthalpy wheel heat/energy recovery system. The MEP systems alone were responsible for 33 of the 55 of the LEED points attained to achieve a LEED-NC Platinum certification for this project (the first LEED Platinum community college in the country). The systems will help to save more than $2.6M in operating expenses over the next 25 years.

• Building Design and Construction Magazine 2009 Gold Team of the Year Award, Health Science and Technology Center

• CCC/IOU Partnership's Community College Sustainability Best Practices Award Overall Sustainable Design Category of New Construction & Major Rehabilitation

• Community College Facility Coalition (CCFC), Design Award of Merit, August 1, 2008

• Silicon Valley/San Jose Business Journal Structures, Best Green Project, October 1, 2008

• US Environment Protection Agency (EPA), Environmental Awards Environmental Hero, February 1, 2008

•

California Construction Magazine Best of 2008 Awards Program, Winner, Green Building Category

H I G H E R E D U C AT I O N

STANFORD UNIVERSITY CLARK CENTER R&D FACILITY

Palo Alto, CA

Type: R&D Laboratory Size: 200,000 SF

This 200,000 SF project is a multi-story building on the Stanford University campus dedicated to biotechnology research and development. The firm was responsible for the design of the HVAC, fume exhaust, building automation, and peer review of the plumbing/process piping systems.

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SOKA UNIVERSITY OF AMERICA

Aliso Viejo, CA

Type : Campus Expansion, Labs Size : 200,000 SF

AlfaTech is providing mechanical, electrical, and plumbing design services for this university campus expansion project located near Irvine, CA. The Engineering / Science / Lab / Admin Building will be 4 stories and approximately 100,000 SF with classrooms, administrative offices, and wet and dry labs. The Resident Housing facility will be 4 stories and comprised of approximately 75 to 80 rooms.

Both proposed projects will be designed to accommodate a LEED Gold Building Certification, and an exterior architectural design pallet that will respect the current design features, landscaping and cultural aspects of the campus.

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SKYLINE COMMUNITY COLLEGE

San Bruno, CA

Type : New Construction, Modernizations Size : 155,000+ SF

Projects: • New Science Annex - 21,236 SF • New Student Union Building – 43,750 SF • New Facility Maintenance Building – 15,000 SF

• Building 7 Modernization – 35,000 SF • Building 8 Modernization – 35,000 SF

The firm provided mechanical and electrical engineering services for new construction and renovation projects on the Skyline Campus for both the traditional ‘design-bid-build’ and for ‘design-build’ project delivery method.

We also provided the bridging documents for the above “Design Build” projects on the campus, including the new 43,750 SF Student Support and Community Center (Student Union) and 21,236 SF Science Annex Building. The building accommodates the following services: bookstore, common reception area, associated students offices and senate chambers, student activities offices and storage, multi-cultural center, security office, food service, meeting center, student health services and information, chemistry department with labs, biology department with labs, and a bridge connection. The gross building area is 63,000 SF.

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MONTEREY PENINSULA COLLEGE

Monterey, CA

Type: New Construction and Modernizations

Projects: • New Child Development Center Building • Modernization of Administration Building • Modernization of Computer/Business Center • Modernization of Lecture Forums • Modernization of Gymnasium • Modernization of Humanities Building • Modernization of Performance Art/Theater Building

Monterey Peninsula College is an ongoing client. AlfaTech provided MEP and Technology engineering design services for this project. One project included providing design for new site utilities upgrades including new 21KV distribution system, new communications and power distribution to building, gas, water, storm drain, and grey water systems coordination. The project scope also included energy efficient gym lighting, theater lighting, exterior lighting and energy control systems for targeted areas on campus. The lighting was designed with integrated occupancy sensors, photosensors and building management system control for maximum energy savings.

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COLLEGE OF MARIN – LEED GOLD

Kentfield and Indian Valley, CA

Type: New Construction, Additions and Modernizations Size: 170,000+ SF

Projects: • Physical Education Building Remodel (Kentfield) – 44,000 SF • Science/Math/Central Plant Complex (Kentfield) - 60,000 SF • Transportation Technology Complex (IVC) – 10,000 SF • Main Building Complex (IVC) – 36,000 SF • Campus Master Planning for Kentfield and Indian Valley Campuses The firm was selected to provide all up-front engineering services relating to all planned bond projects including the master planning, district-wide energy modeling, district-wide mechanical, electrical and plumbing facility assessments and design standards for the District with projects totaling over 170,000 SF. We provided engineering design services and design and construction administration for the renovation of the Diamond P.E. existing complex. The project included new HVAC and electrical distribution. An energy management control system (EMCS) links directly to the new central campus EMCS system on the central part of the Kentfield campus. The project also includes a photovoltaic system which will either provide electrical for distribution in the building or supplemental hot water for the swimming pool. The Science/Math/Central Plant on the Kentfield campus includes a new energy efficient, geothermal underground / renewable energy HVAC system. The new 650- Ton, 340 vertical bore geothermal system provides heating and cooling via ground coupled water source heat pumps to the new Complex and Fine Arts buildings as well as two campus pools. The field was designed and phased for future expansion to support the entire Kentfield campus. The Transportation Technology facility on the Indian Valley campus required the total renovation of 10,000 SF which includes automobile technology repair facilities and instructional offices. The facility includes a radiant floor heating system and a solar thermal system to provide domestic hot water. In addition, the firm is working with the Kentfield campus on the Larkspur Annex to upgrade the electrical services and distribution to create a staging area for future campus construction.

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STANFORD UNIVERSITY

Palo Alto, CA

Type: New Construction , Additions, Renovations Size: 200,000+ SF

AlfaTech provided engineering services for a multitude of buildings on the Stanford University campus. For the Mechanical Engineering Building, the firm provided new systems for existing 46,000 SF two story building. For the Law School Building, the firm provided a feasibility study of campus steam/chilled water to a new Student Health Center, a new Student Services Building, and a proposed Law School Student Center. The firm provided design for a new 50,000 SF, 3-story building to house the Graduate School of Business. The Keck Laboratory was a new 72,000 SF, three-story lab. The firm provided additions & renovations to the Medical Center Teaching Hospital. The firm also provided design services for a new Environmental Safety, 30,000 SF hazardous waste monitoring & storage facility, and systems renovation to the South Hall Cafeteria.

STANFORD UNIVERSITY / AUXILIARY LIBRARY

Livermore, CA

Type: New Construction, High Security Storage Library Size: 38,000 SF

The firm was a key part of the mechanical, electrical, telecommunications, and security design team for this state-of-the-art, 38,000 SF building which is the most secure facility of its kind in the West. Designed to protect over a $1 billion worth of books and journals, the building will maintain archival conditions of temperature and humidity to preserve the books for a minimum of 200 years. Exact temperature and humidity control and attention to detail are keys to preserving this treasure trove of academic knowledge.

H I G H E R E D U C AT I O N

DIABLO VALLEY COLLEGE

Pleasant Hill, CA

Type: Higher Education Size: 80,000 SF

AlfaTech provided full MEP/FP engineering design and sustainability services for this 80,000 SF educational facility. This facility houses a wide range of services and amenities for the college. This colleges includes admissions office, career center, food services, School of Hotel & Restaurant Management, and the dean’s office.

Some of the sustainable features include:

Natural ventilation

•

Radiant floor

•

Chilled beams, and

•

• A high efficiency central plant

H I G H E R E D U C AT I O N

EVERGREEN VALLEY COMMUNITY COLLEGE

San Jose, CA

Type: New Construction and Modernizations Size: 100,000+ SF

A client for a number of years, one of the many projects for this community college included the new 2-story 70,000 SF Library/Educational Technology Center containing open lab, distance learning, and support areas as well as a7,500 SF basement area housing tech support, cable studio, and 3,000 SF mechanical space. Other projects included MEP and Technology design of the new 2,200 SF Fine Arts Center and modernization of the 20,000 SF Chemical Lab and Administration Building.

CITY COLLEGE OF SAN FRANCISCO

San Francisco, CA

Type: New Construction Size: 537,000 SF

The firm provided master planning and infrastructure design services for the City College of San Francisco’s new Ocean Avenue campus. The campus will house eight new buildings including a performing arts center, advanced technology building, joint use facility, central plant (part of joint use building), classroom building, dormitory, and bookstore totaling 437,000 SF. The College’s project goals included the buildings be designed and certified to a minimum LEED Silver rating. We also provided MEP, and sustainable design for the AIA Award Winning, new performing arts complex spanning 100,000 SF. Green Features: Radiant Heating & Cooling, Green Roofs, Natural Ventilation, Photovoltaics.

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SANTA ROSA JUNIOR COLLEGE / STUDENT SERVICES BLDG

Santa Rosa, CA

Type: New Construction Size: 80,000 SF

AlfaTech provided mechanical and electrical engineering design for this project. Sustainable features include a geothermal underground / renewable energy HVAC system. Scope includes offices, food service, kitchen, student dining, information services, and a bookshop. The building features two heavy use kitchen areas with a combined capacity to serve 420 faculty, staff, and students.

SANTA ROSA JUNIOR COLLEGE / CULINARY ARTS BLDG

Santa Rosa, CA

Type: New Construction Size: 70,000 SF

AlfaTech provided mechanical and electrical engineering design for this project which includes four restaurant grade kitchen/classroom areas, student lecture classrooms, and office area for administrative staff. The teaching kitchen areas have a capacity for 25 students and each kitchen features type I (grease) and type II (vapor) exhaust systems. All exhaust systems feature Variable Flow Hoods which considerably reduces exhaust fan energy consumption. All make up air is provided by a 50,000 CFM AHU with FanWall technology that allows the air flow range to vary by using an asymmetrical VFD assignment to the FanWall fan array. Air conditioning is achieved through the use of zoned heat pump units water cooled through two closed circuit cooling towers. The building is also equipped with a solar thermal array sized to provide all domestic hot water needs of the building, including the kitchens.

H I G H E R E D U C AT I O N

SAN FRANCISCO STATE UNIVERSITY

UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

UNIVERSITY OF CALIFORNIA, BERKELEY

San Francisco, CA

Berkeley, CA

San Francisco, CA

Type: Design Review and Existing Conditions Study, Remodel Size: Various

Type: Modernizations Size: 124,000+ SF

Type: New Construction and Modernizations Size: Various

Projects: • Mary Ward Hall • Franciscan Building - 14,000 SF • Administration Building

Projects: • Buildings 6 and 80 • Computer Room Remodel • Cory Hall • McCone Hall

Projects: • Lecture Halls • Teaching Rooms • Computer Lab • Biomedical Research • Café and Food Lounges

The firm completed the design of mechanical and electrical systems for several projects for San Francisco State University. For Mary Ward Hall, the firm was engaged to do the peer review of the design-build contractor’s mechanical and electrical construction drawings, specifications and product submittals for compliance with the stated scope of work outlined by the University. The firm provided engineering design services for the complete mechanical and electrical plan-and-specification design of interior remodel/improvements of the first and second floor office area, approximately 7,500 SF, located in the Administration Building of the SFSU campus.

The firm provided engineering services for numerous projects at UC Berkeley which include full systems renovation to Advanced Light Source structural biology support encompassing 16,000 SF to buildings 6 and 90, Cory Hall which was a new 28,000 SF fifth floor built on top of existing electrical engineering building and MEP and fire protection renovation to McCone Hall which was an 80,000 SF classroom.

The firm provided two separate concurrent projects for value engineering of library release space improvements. The project realized two new lecture halls, 18 teaching rooms, a computer lab, biomedical research facilities, relocation of café and expansion of student lounges.

JFK UNIVERSITY Pleasant Hill, CA

Type: New Construction Size: 107,000+ SF

CALIFORNIA STATE UNIVERSITY, BAKERSFIELD Bakersfield, CA

The firm provided full engineering services for the JFK University new law school facility including classrooms, libraries, building services, faculty and staff admin areas, storage, and break rooms.

Type: New Construction Size: 153,000+ SF

The firm provided full engineering design for the new Stern Library. This library features a workshop space with a clean booth, a television studio, and a sound recording booth. All new engineering systems were connected to central campus facilities, which included mechanical, electrical and plumbing systems.