AlfaTech BioTech

INNOVATIVE IDEAS | INTEGRATED SOLUTIONS | SUSTAINABLE PARTNERS

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OVERVIEW / Profile & Services

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Sustainability

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Markets & Relevant Projects

OVERVIEW 01

Profile & Services

P R O F I L E

AlfaTech has built its reputation on providing the most innovative and sustainable engineering solutions from master planning through construction administration. Our presence is not only California and Atlanta, but also internationally. Our clients include numerous large multi-national firms, many ongoing clients we’ve been serving for years. We strive to provide intelligent and innovative strategies starting with project inception, in order to provide maximum benefit to our clients during the entire development process whether it be new high-rise projects, mixed use projects or revitalization of existing communities. Our team provides the most appropriate engineering design solutions which are highly efficient and cost effective, and promotes the greatest possible return on investment for our clients. Our goal is to build the most dynamic relationships, be attentive to the needs of our clients and partners, and be true team players. With this mindset, we’ve built a stellar list of clients.

Uber, Mission Bay 1 & 2

Eventbrite

eBay

UNITED STATES San Francisco San Jose Los Angeles Atlanta

INTERNATIONAL Europe Asia Middle East Latin America Africa

AlfaTech RSBG Infrastructure Dorsch Gruppe Qvest Media SecurView

Additional Resources Through Our Sister Companies

100+ locations | 55+ countries | 3,600+ staff

S E R V I C E S

MECHANICAL ENGINEERING DESIGN HVAC

ARCHITECTURAL LIGHTING DESIGN Lighting and Lighting Controls Lighting Calculations

COMMISSIONING | ENERGY SOLUTIONS Early Quantifiable Energy Study Incentives

Heating Systems Water and Gas Cooling Systems / Chilled Water Dehumidification Systems Contamination Sensitive Areas Industrial Hygiene Systems Low Tolerance Temp Control Title 24 Analysis and Design Heat Recovery Systems Central Utility Plants Air Handlers HVAC System Controls PLC Programming Fire Protection and Plumbing

Customized ROI Calculations Sustainable Lighting Design

Energy Star® Assessments Retro-commissioning (RCx) Monitoring Brand Continuous Commissioning (MBCCx) ASHRAE Level 1, 2 and 3 Energy Audits Measurement and Verification (M&V) of installed projects Energy Modeling Net Zero Energy Budgeting HVAC/Chilled Water Plant Optimization

Energy Savings Analysis Custom Lighting Fixtures Design for finishes, fabrics and light sources

TECHNOLOGY DESIGN Low Voltage Design Security Design Audio Visual Design Wireless Design & Modeling

PROCESS Industrial Waste Collection Acid Neutralization Bio-Kill Waste System Process Waste Containment Ultra pure De-ionized Water Systems

Strategic Consulting Project Management Relocation & Migration

ELECTRICAL ENGINEERING DESIGN Power Systems

Emergency & Standby Power Lighting and Lighting Controls Security Systems 24 / 7 Power Systems (UPS) Power Monitoring Systems Toxic Gas Monitoring Graphic Control and Alarm Panels Grounding and Bonding

USP Water WFI Water Specialty Chemicals Chemical Storage

SUSTAINABILITY Sustainability Planning (Organizational and Infrastructural) LEED / Green Building Consulting Masterplanning Life Cycle Cost Assessment Occupant Wellness and Comfort

Lab and Special Gas Systems Ultra High Purity Gas Piping

Bulk & Specialty Gases Toxic Materials Handling Code Compliance Process Distribution Piping Process Cooling Water Medical Gas Medical Vacuum Waste Anesthetic Gas Disposal system (WAGD)

Energy Management Energy Conservation Fire Alarm Systems Public Address Systems Plug Loads Control

Façade Engineering CFD / Wind Studies Wind Studies Thermal Stratification Studies Energy Concept Studies

Dental Vacuum System Dental Water System

S E R V I C E S

GREEN BUILDING

SUSTAINABILITY

LIFE

MECHANICAL ENGINEERING DESIGN

ELECTRICAL ENGINEERING DESIGN

OF A BUILDING RETRO COMMISSIONING

ARCHITECTURAL LIGHTING

TECHNOLOGY

COMMISSIONING / ENERGY SOLUTIONS

CONSTRUCT I ON

OCCUPANCY

END OF USE

DES I GN

C L I E N T S

JDS Uniphase Corporation John Muir Medical Center Johnson & Johnson Johnson Controls JP Morgan Chase JRH Biosciences Juniper Networks Junipero Serra High School Kaiser HealthConnect Kaiser Permanente Kasowitz, Benson, et al

Novell Novellus Systems NVIDIA Ohlone Community College OptiSolar Oracle Orchard Properties Oread Pacific Bell PDL BioPharma PG&E Panattoni Europe Pfizer Philips Semiconductor Pitney Bowes Polycom Port of San Francisco Presidio Trust Price Waterhouse Coopers Qualcomm Queens Medical Center Rambus Raytheon Company

Scripps Memorial Hospital Sequoia Hospital CHW Sequoia UHSD Siemens SLAC National Accelerator Laboratory Solectron Corporation Sony America Spansion Sprint SRI International (Stanford Research) Stanford Healthcare & Clinics Stanford University Stanford University Medical Center

365 Main 3M Company AARP Abbott Biotherapeutics Abbott Laboratories Abbvie Abgenix Abt Associates ACCO Engineered Systems Adaptec AOC Adobe Systems Advanced Micro Devices Advantest America Advent Software Aetna Affymetrix Agilent Technologies Agnes Medical Center Akamai Technologies Alcoa Allen, Matkins, et al Alliance Bernstein, LLP Alta Bates Health System Altera Corporation Alum Rock School District Alza Amazon/Lab 126 Ambiance Associates Ambience Interiors Amdocs American Express Company Amgen Amprius

Bingham McCutchen, LLP Bio-Rad Laboratories BioGenex Biomarin Pharmaceutical BioMed Realty Trust Bloom Energy BMC Software Booz Allen Hamilton Inc

County of Sacramento County of San Mateo County of Santa Clara Credence CSAA

CSU Northridge Cupertino USD Daughters of Charity Health Dell Deloitte Consulting Digital Realty Trust Dignity Health Dominican Hospital Dropbox Dupont East Side Union HSD eBay Eil Lilly & Company Elsevier Inc Emirates National Oil Empire State Development Equinix Equis Corporation Ericsson Ernst & Young LLP Exelixis Ferrari Maserati of Silicon Valley Fidelity Investments Fireman’s Fund Insurance First Franklin Financial Corp Flextronics Foundry Networks Franklin Templeton Investments Genencor Genentech General Dynamics General Electric Genzyme Corporation Gilead Sciences Goldman Sachs Good Samaritan Hospital GSA Harbor UCLA Medical Center Hayward USD

Boston Properties Boston Scientific Bradford Schools Bristol-Myers Squibb Broadcom Broadreach Capital Partners Brocade Buck Institute Stem Cell Research Lab Cadence Design Systems Cal Pacific Med Center California Department of Mental Health CarrAmerica Development Cedars-Sinai Medical Center Chabot Las Positas CCD Charles Schwab Chevron Children’s Hospital, Los Angeles County Children’s Hospital, Oakland Children’s Hospital, Orange County Children’s Hospital, San Antonio Chinese Hospital Cisco Systems Citigroup Realty Services

Kimpton Hotels KLA-Tencor Corp La Clinica De La Raza

Stion Corporation Stryker Endoscopy Stubhub Sun Microsystems SunPower Sutter Health

Lam Research Laney College

Lawrence Berkeley Lab Letterman Digital Arts Levi Strauss & Company Linear Technology LinkedIn Lockheed Martin Corp Logitech Longs Drug Stores Los Gatos Saratoga HSD Lumentum Marriott International Martin Luther King, Jr. Community Hospital Marvell Semiconductor Maxim McKesson Medarex Menlo Park City School District Mercy Southwest Hospital Microsoft

Sybase Inc Symantec Synopsys Inc Sysorex T-Mobile Tencent Tesla Motors The Gap Twitter Uber UC Berkeley UC Davis UC Davis Medical Center UC San Francisco

Regional Medical Center Riverbed Technologies Robert Half International Roche Bioscience Ross Stores Sacramento Municipal Utility District Safeway Saint Francis Memorial Hospital Saint Joseph Hospital Saint Louise Regional Hospital Saint Mary’s Hospital Samaritan Medical Center Samsung San Francisco City Hall San Francisco International Airport San Francisco USD San Jose Medical Center San Jose Redevelopment Agency San Jose State University San Jose USD San Mateo CCCD San Mateo County Office of Education Sandia Laboratories Santa Clara County Health Dept. Santa Clara County Library Santa Clara County Office of Education Santa Clara USD Santa Clara University

City of Cupertino City of Foster City

UC Santa Cruz UC Los Angeles UCLA Outpatient Surgery/Oncology Center UCSF Mission Bay Medical Center Ultratech University of Colorado Hospital

City of Fremont City of Monterey City of Mountain View City of Newark City of Oakland City of Palo Alto City of Sacramento City of San Jose

Amstein + Walthert Anderson Architects Anixter Applied Dynamics Applied Materials Aradigm AT&T Park Clinic Atmel Corp Autodesk Avaya Avid Technology Avidex BAE Systems Bank of America Banuazizi Architects Bayer Healthcare Bechtel Corporation Bell, Rosenberg, et al Berryessa USD

Mills/Peninsula Hospital Mission Oaks Hospital Molecular Devices Monterey Peninsula College Morgan Hill USD Morgan Stanley Morrison & Foerster Motorola Mountain View School District MW Zander NASA-Ames National Semiconductor Network Appliance Nokia Nortel Networks North Bay Medical Center Northrop Grumman Novartis

University of Nevada University of Virginia URS Valley Medical Center Verisign Verity Health Verizon Communications Veteran’s Administration Visa International Vivus VMware Wachovia Bank

City of San Mateo City of Santa Clara City of Saratoga City of South San Francisco City of Sunnyvale College of Contra Costa College of Marin Colliers International Computer Associates Int’l Compuware CoreSite County of Monterey

Hewlett Packard Highland Hospital Hitachi America IBM Impax Laboratories Informatica Corporation Intel InterMune Intuit J&W Scientific

SAP Labs LLC Saratoga USD Savvis

Washington Hospital Xoma Therapeutics Yahoo

SUSTAINABILITY 02

S U S T A I N A B I L I T Y

At AlfaTech, we have a multidisciplinary team of experts to assess and design projects with a holistic approach. Working alongside owners, architects and other stakeholders, we examine every project in a comprehensive, systematic way to meet the client’s sustainability, energy, water and environmental quality goals. AlfaTech goes beyond engineering – our suite of energy, water and sustainability assessment services creates projects that benefit the bottom line. We provide expert studies in all qualitative aspects of the built environment such as day lighting, thermal comfort, advanced lighting control design, and technology integration.

We examine every project with a comprehensive systematic approach to meet the client’s sustainability, energy, water and environmental quality goals.

S U S T A I N A B I L I T Y

ADVANCED SIMULATIONS

We provide various advanced computer simulations to study wind patterns, thermal stratification and comfort issues in spaces, building façade studies and energy modeling to aid architects and owners make key decisions during the early stages of design.

Façade Engineering CFD/Wind Studies

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Thermal Stratification Studies

Energy Concept Studies

Energy Modeling

S U S T A I N A B I L I T Y

CASE STUDY:

UBER MB 1 & 2 MISSION BAY HEADQUARTERS

San Francisco, CA

AlfaTech is currently involved in this Uber’s new San Francisco presence which is a new 420,000 square-foot, ground up office building in the Mission Bay area in San Francisco. Our scope of work includes mechanical, electrical, plumbing, technology, security, and sustainability services. AlfaTech assisted the architectural design team with optimizing performance by assessing various utility, façade and wind studies. The project is designed as an innovative, ultra- high performance building that includes a façade that responds to programmatic needs, an under floor air distribution system, a “winter garden” which acts as the main social space incorporating natural ventilation, and a proposed geothermal system to substantially reduce cooling equipment needs. AlfaTech has been providing MEP Engineering and Technology services for this client in the US and Globally for ten sites, including the new corporate headquarters in San Francisco. This is a state of the art new campus with over 420k SF of offices, a full kitchen and cafeteria. The project will include evaluation of all available sustainability features. Sustainability goals: • Significant reduction of building energy cooling needs by the use of geothermal exchange systems • Aggressive rainwater capture and retention • Natural ventilation for main atrium social areas, creating a pleasant, open experience for employees and visitors • Maximize use of day lighting to optimize workspace quality

S U S T A I N A B I L I T Y

CASE STUDY:

LENNAR CANDLESTI CK POINT & HUNTER’S POINT MASTER PLAN San Francisco, CA

The Candlestick Point and Hunter Point Shipyard is a 702-acre development that has the potential to bring most dynamic companies into the area and develop whole communities. This area will house R&D facilities, commercial spaces, multi- use buildings and retail spaces. Parks, trails, and open spaces will be additional features that will attract and enhance the community. The new development will add over 10,000 new residential units in the form of condominiums and low-, mid- and high-rise buildings. There will be over a million square feet of commercial space made available, over three million square feet for Research and Development, as well as over 300,000 square feet of property devoted to community activities. AlfaTech views this holistic approach to community development as an opportunity for Lennar Urban to be at the vanguard of urban design by creating a community infrastructure focused on environmental sustainability, technology, and self- sustaining. This means taking advantage of existing technologies to generate energy with the lowest environmental impact. We conducted a series of sustainable mechanical studies in a master plan scale to help the owners understand the options available to explore the feasibility of Net Zero energy for the new development. Proposed strategies involve:

Geothermal heat rejection systems

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• High performance chillers and thermal energy storage • Biodigestion system for heat recovery and energy generation • Solar photovoltaic array for electricity generation • Rainwater and gray water capture and treatment

S U S T A I N A B I L I T Y

CASE STUDY:

DELTA PRODUCTS HEADQUARTERS Fremont, CA

Delta Products desired a new headquarters highlighting sustainability and energy efficiency with primary goals to showcase Delta Products’ innovation in a state of the art building blending the natural surroundings with sustainable building design. The Delta Americas Headquarters is a three-story 250,000 SF campus consisting of private offices, administrative, open workspace, conference/auditorium facilities, kitchen/dining areas, labs, office and warehouse. AlfaTech provided sustainable mechanical electrical plumbing engineering design services for this project focusing on the client’s desire to maximize natural ventilation and daylighting reduce water and energy consumption with a geothermal central plant and utilize radiant systems for primary space conditioning. AlfaTech conducted extensive CFD modeling to assist with sizing and locating windows around the building and their integration into a thermal tower ventilation strategy. The project also encompasses a photovoltaic system to balance energy consumption and achieve Net Zero Energy.

Some of the features included are:

Ecological ponds

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Ground source heat pumps

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EV chargers

Solar energy system Natural ventilation Active chilled beam

Rainwater harvesting

• Elevator power regeneration systems • Energy efficient HVAC system • Energy storage solutions • Hydronic bidirectional heating/cooling flooring systems

LED lighting

Spectrally selective glazing Grass and native plants

We believe making the world a better place is a responsibility we all share. And being able to do our part in the way we work is one of the best ways we can give back and have a positive effect on our environment. This means, not only do we always strive to provide the most sustainable solutions for our clients, but we are also always working on new, innovative and pioneering methods to bring sustainability to the next level, staying ahead of the curve in all types of projects in all the markets we serve.

Let’s leave the world a better place than we found it.

03 MARKETS

& Relevant Projects

BIOTECH

B I OT E C H

ABBOTT BIOTHERAPEUTICS

Redwood City, CA

Type: Data Center, Campus Size: 400,000 SF with central Data Center

AlfaTech was selected as a turnkey firm to design and build Abbott's 400,000 SF new headquarters campus. The facility now houses an Abbott spinoff company called AbbVie. This project includes a 4,000 SF raised floor data center, tenant improvement of offices, along with laboratory facilities, and vivarium (animal care facility). A pilot plant (cell culture and purification) was built on the first floor along with new laboratory facilities, offices, and service yard. AlfaTech was fully responsibly for programming, design and construction of this state-of-the-art campus which the budget and schedule was guaranteed as a part of our highly successful single-source project delivery method.

B I OT E C H

STANFORD UNIVERSITY CLARK CENTER R&D FACILITY

Palo Alto, CA

Type: R&D Laboratory Size: 200,000 SF

This 200,000 SF project is a multi-story building on the Stanford University campus dedicated to biotechnology research and development. The firm was responsible for the design of the HVAC, fume exhaust, building automation, and peer review of the plumbing/process piping systems.

B I OT E C H

BUCK INSTITUTE STEM CELL RESEARCH LAB

Novato, CA

Type: Lab, Animal Handling facility Size: 60,000 SF

AlfaTech provided project management and mechanical and electrical engineering services for this project. Systems include the addition of a ground coupled geothermal system, which provides heating and cooling to the new addition and the existing 60,000 SF lab facility. Geothermal ground water at 61 degrees will be used to condition lab fume hood make up air, freeing up 300 tons of cooling from the existing central plant. The additional chilled water tonnage will be used for the new addition. The new geothermal system will provide all cooling & heating for the existing & new 60,000 ft2 lab building, and “no additional tonnage” will be required for the existing central plant. The geothermal system will also save 7,500.000 gallons of water a year from being evaporated via the existing (now decommissioned) cooling towers.

B I OT E C H

ALZA

Various Bay Area Sites

Type: Laboratories, Manufacturing, Biocenter, Vivarium, Office, Pilot Plant Size: 1, 000,000+ SF

Projects: Vacaville cGMP Facilities: • Original Manufacturing Building • Aqueous Tablet Coater • Fluid Bed Dryer • High Shear Granulation • Pharmaceutical Processing Area • Tablet Coating Process • Methylene Chloride Distribution Mountain View Facilities: • Buildings M2 & M3 Biocenter • M1 Pilot Plant & Research Center

• Palo Alto Facility: • Buildings M8 & M9 • Underground Tanks

Alza Corporation (a Johnson & Johnson Company) is a research-based bio- pharmaceutical company with leading drug delivery technologies. AlfaTech has provided design services for various Bay Area sites listed above.

B I OT E C H

GENENTECH

South San Francisco, CA

Type: Laboratory Size: 100,000 SF

AlfaTech provided a new $1.1 million, 2-story facility for animal research labs and support areas. The mechanical design features double-duct, double-fan, constant volume mixing boxes with HEPA filtration. In addition, the firm provided full facility design services for Genentech’s Vacaville campus under a Master Services Agreement. This work encompasses office space, laboratory and cGMP manufacturing.

GILEAD SCIENCES

Foster City, CA

Type: Laboratory, Office, Manufacturing Size: 500,000 SF

AlfaTech provided MEP and telecommunications design for Gilead’s campus consisting of 16 buildings including administrative and private offices, development labs, pilot plants and cGMP therapeutic manufacturing / production areas. The firm also provided MEP engineering design services for Gilead’s 35,000 SF pilot plant on the Foster City campus as part of a previous project.

B I OT E C H

GENENCOR

Palo Alto, CA

Type: Laboratory, Offices, Pilot Plant Size: 77,500+ SF

This International Technology Center facility combines basic research, pilot plant development, and robotics under one roof. This cGMP project required complete equipment layout, installation design for a pre-manufactured fermentation skid, tank design, and design of three automated 1,500-liter recovery vessels.

BIOMARIN PHARMACEUTICAL GALLI EAST EXPANSION (BGEX)

Novato, CA

Type: cGMP Manufacturing Size: 20,000 SF

AlfaTech’s services included management oversight of facilities operations for the manufacturing plant during facility validation. Scope included management of standard operating procedures, spare parts, training of new systems, turnover of systems and facility from contractor to Biomarin and plant engineering services.

B I OT E C H

BAYER HEALTHCARE

NEKTAR PHARMACEUTICALS

XOMA THERAPEUTICS

Berkeley, CA

San Carlos, CA

Berkeley, CA

Type: Manufacturing Plant Size: 40,000 SF

Type: Laboratory, Office, Manufacturing Size: 4,000 SF

Type: Manufacturing, Research Size: 8,000 SF and 10,000 SF

AlfaTech was selected to perform design construction management services for the replacement and upgrade of the B55 WFI system. The state-of-the- art replacement WFI system consisted of a single HWFI loop with multiple POU heat exchangers. WFI temperatures at the POUs were controlled using HMI panels. The firm scope of work included: interviews with the users to determine WFI consumption; production of complete WFI design-built and demo bid packages; procurement of owner-furnished components; selection of a design-built contractor; and management of the final design and construction effort.

AlfaTech provided design services for the consolidation of the central data center, which will occupy approximately 4,000 SF in a currently unoccupied space for Building 3.

For the Pilot Plant, the project includes conversion of the X-5 pilot plant to a combination of manufacturing and research. Modifications were made to the existing facility, bringing it to current ADA standards, and generally “state-of- the-art” status. For the cGMP warehouse facility, the firm provided full design services which entailed the renovation of an existing facility along with validation support and construction management. The warehouse concept entailed the renovation of an existing facility along with validation support.

VIVUS Lakewood, NJ

Type: Laboratory, Manufacturing Size: 80,000 SF

XOMA THERAPEUTICS Berkeley, CA

AlfaTech acted as the owner’s principal engineer for design of a facility that expanded their capacity to formulate and produce a new drug and drug delivery system. The scope of work involved HVAC, process utilities, R.O./D.I. and hot USP water systems, production room layout, and general engineering support. AT also worked closely with the validating agency to provide a complete turnover package.

Type: Fermentation Suite Size: 5,000 SF and 12,000 SF

BAXTER HEALTHCARE Hayward, CA

For the 5,000 SF Fermentation Suite, AlfaTech provided full design and construction management for its GMP new 2,000 liter fermentation suite along with validation support. Design for the 12,000 SF Suite provided a new cGMP fermentation suite consisting of 50 L, 130L, 500L, 2750L, and 12,000L fermenters. These were fully automated with CIP and SIP capability. In addition, a number of media preparation and purification vessels were specified.

Type: Laboratory

This Hyland Division Laboratory renovation project involved a complete remodel and relocation of the biotechnology process rooms. Construction documents and validation for a cGMP upgrade of the existing facility were also required.

THE JACKSON LABORATORY WEST West Sacramento, CA

Type: R&D Laboratory Size: 91,000 SF

AlfaTech provided MEP design services for interior improvements to an existing tilt-up concrete warehouse, as well as an expansion into an existing facility. The new use of this space includes West Coast regional offices, animal vivarium, wash/sterilization facilities, various research laboratories, animal shipping/staging/support spaces, mechanical yard, and parking .

B I OT E C H

OREAD

JRH BIOSCIENCES

COLLAGEN AESTHETICS INC.

Palo Alto, CA

Woodland, CA

Fremont, CA

Type: Laboratory & Manufacturing Size: Robotics Lab, 1,000 SF, Chemistry Lab, 10,000 SF Facilities:

Type: Manufacturing Plant Size: 30,000 SF

Type: Manufacturing Plant Size: 12,000 SF Facilities: • Bulk Processing Area Addition • Office Space Tenant Improvements • Warehouse and Office Space

• Chemistry Lab • Robotics Lab • WFI/USP Water System

This facility produces media for cell metabolism studies and growth kinetics. It is also used for the research, development and manufacture of proprietary client products. Process piping included a WFI system with a high temperature (85°C) and ambient (25°C) loop and all necessary controls; a clean steam and plant system complete with boiler feed water pump system and blow down cooler; R.O. piping loop and system; process cooling water system with fluid cooler and chilled water heat exchanger; and process gases.

Oread is a contract provider of comprehensive contract drug development, clinical trial support, finished product manufacturing and packaging, and regulatory support for the pharmaceutical industry. AT provided full engineering services for a robotics dissolution laboratory and the installation of a new formulation chemistry facility with a cGMP WFI system (1,000- gallon storage capacity). Extensive fume hoods contain MRI lab system and sterilizer. AT worked closely with the client during the programming phase and to make sure that the robotics facility, which features a robotically-controlled vial-fill system, would be validatable. The firm also managed the preparation of mechanical, electrical, plumbing, and process designs to meet city permit deadlines.

Collagen Aesthetics Inc. develops, manufactures, and markets on a worldwide basis high quality biocompatible products for the treatment of defective, diseased, traumatized or aging human tissues. This project modified existing Class 100 – 10,000 spaces for laminar flow filling suites for new product manufacturing. The firm maintains Collagen’s library of as-built drawings to support ISO 9001 certification.

ARADIGM Hayward, CA

AMGEN BUILDINGS 31 AND 42 Thousand Oaks, CA

Type: Pilot Manufacturing Plant Size: 20,000 SF

Type: cGMP Manufacturing, Office Size: Building 31, 10,000 SF; Building 42, 15,000 SF

Aradigm is engaged in the development of novel pulmonary drug delivery systems designed to enhance the delivery and effectiveness of a number of existing and development stage drugs and reduce the need for injectable drug therapy. Clinical trial Phase III quantities of three new products for inhalation therapy will be produced at the new full-scale cGMP clinical and manufacturing facility. AlfaTech also provided services at Aradigm’s 30,000 SF production facility. The project has extensive clean rooms, including Class 100 laminar flow processing areas; a WFI generation and distribution system; and high purity gas distribution.

Amgen is a global biotechnology company that discovers, develops, manufactures and markets cost-effective human therapeutics based on advances in cellular and molecular biology. A large-scale dispensing suite was added to Building 31, and Building 42 was a new cGMP raw material receiving facility. On Building 31, AlfaTech provided mechanical, electrical, plumbing, support utility design, specifications, and specialized equipment sourcing for construction of cGMP raw material dispensing suites within an existing warehouse and distribution facility. Building 42 was programmed and designed for cGMP raw material receiving and support for Building 23, a clinical trial manufacturing facility. Process engineering design included liquid caustic solution receiving, storage and transfer systems, and fresh and waste glycerol streams storage and transfer systems.

SLAC NATIONAL ACCELERATOR LABORATORY Palo Alto, CA

Type: FEH Hutches 4, 5, &6

AlfaTech provided a feasibility study for the FEH Hutches 4, 5 and 6 project to define alternate system solutions for the HVAC design. The project was in the final design phase using a single unit air handling system. The distribution system was going to occupy space that the owner wanted to reserve for future use. We provided a conceptual design study to evaluate how much space could be saved using a different system. The study included pros and cons of each system, sketches for cost estimating and peer review of existing design documents.

INNOVATIVE IDEAS | INTEGRATED SOLUTIONS | SUSTAINABLE PARTNERS

LOS ANGELES

SAN FRANCISCO

SAN JOSE

510 West 6 th Street, Suite 1105 Los Angeles, CA 90014

One Post Street, Suite 2200 San Francisco, CA 94104

1321 Ridder Park Drive, Suite 50 San Jose, CA 95131

213.212.9860

415.403.3000

408.487.1200