AlfaTech Qualifications_Takeda San Diego

AL FATECH LOCAT IONS San Jose, California – HQ | San Francisco, California | Ventura, California | Monrovia, California | San Diego, California | Atlanta, Georgia

INNOVAT I VE I DEAS | SUSTAINABLE SOLUT IONS | INTEGRATED PARTNERSH I PS

Table of Contents

Firm Profile

01

Engineering Studio

02

03

Project Experience

04

Project Team

ALFATECH PROFILE

2022

Vela Tech Holdings, Inc. established as holding company for AlfaTech and other business units.

2020

S&K Engineering of Monrovia and LFA Lighting of Ventura join our growing firm. Opens San Diego Office

COMPANY PROFILE

2019

Growth of leadership team. Further expansion into international markets with new and existing clients.

2018

Through RSBG: adds strength of 65+ offices throughout Europe, Asia, Middle East, and Africa.

AlfaTech was established in Silicon Valley in 1987 as a mechanical, electrical, and technology (low voltage, security, and A/V) design engineering firm. Responding to client needs, we grew our service offering to include architectural lighting design, sustainability, smart building, and project management services. In addition, we expanded into five California offices, including San Jose, San Francisco, Monrovia, Ventura, and San Diego. AlfaTech is gaining ground through organic, merger, and acquisition growth. Establishing Vela Tech company portfolio with parent company RSBG, our services reach the West Coast to the Midwest and the East Coast from partner offices in Seattle, Chicago, Reston, and Edison. We also have an international presence with offices throughout Europe, Asia, North Africa, and the Middle East. AlfaTech has a solid reputation forged by a corporate commitment to enduring client relationships and service excellence. We provide complete design, design-assist, and design/build project delivery services. Our project experience includes core and shell, tenant improvements, upgrades, repositioning, and restacks. Each AlfaTech project aims to achieve maximum energy performance, resource conservation, and pollution reduction, resulting in the highest energy savings and sustainability at all design phases while creating a balance of preservation, constructability, schedule, and budget. Given the dynamic nature of what we do, our AlfaTech teams are active listeners, and together with their focus on client and partner relations, are true team players.

2017

Expands offices in Los Angeles and Japan. Celebrates 30 Years Success!

2015

Develops partnerships in India, China, Hong Kong and Taiwan.

2014

Merges with Timmons Design. Expands San Francisco office to One Post Street Location

2012

Develops Architectural Lighting Design group. Creates Ireland and Thailand partnerships.

2010

Develops Sustainability / LEED and Energy Solutions groups.

2008

Ranked as one of the Top Five Engineering Firms in Silicon Valley

2006

Merges with MCT. AT-PD founded. Reports annual volume $150M

2003

Named one of the Top 100 Largest Private Companies in San Francisco.

2000

Named one of the Top 100 Fastest Growing Companies in Silicon Valley.

1996

Merges with S&H and MPL. Opens San Francisco office.

1989

Creation of an in-house Technology Group focused on voice, data systems, and overall technology

1987

Jeff Fini, PE, founds AlfaTech MEP Design in Silicon Valley

OUR GEOGRAPHIC REACH

NORTH AMERICA San Jose, California - HQ San Francisco, California Ventura, California Monrovia, California San Diego, California Atlanta, Georgia Seattle, Washington Chicago, Illinois Reston, Virginia Edison, New Jersey EUROPE Leamington Spa, UK Stockport, UK Leeds, UK Wakefield, UK Sunderland, UK Nottingham, UK Manchester, UK Maidenhead, UK Birmingham, UK Bishop’s Stortford, UK London, UK Croydon, UK

Munich, Germany Berlin, Germany Cologne, Germany Frankfurt, Germany Wiesbaden, Germany Hamburg, Germany Ribnitz-Damgarten, Germany

Gujarat, India Dehradun, India Rajkot, India Visakhapatnam, India Tamil Nadu, India Gandhingar, India Manilla, Philippines Indonesia Laos Vietnam NORTH AFRICA Beau Bassin, Mauritis Cairo, Egypt MIDDLE EAST Dubai, UAE Abu Dhabi, UAE Al Ain, UAE Madinat Zayad, UAE Doha, Qatar Riyadh, Saudi Arabia Jeddah, Saudi Arabia Amman, Jordan Baghdad, Iraq

Rostock, Germany Bochum, Germany Stralsund, Germany Copenhagen, Denmark Vienna, Austria Zurich, Switzerland

Madrid, Spain Paris, France Milan, Italy Athens, Greece Istanbul, Turkey Moscow, Russia

ASIA Dhaka, Bangladesh Brahmanbaria, Bangladesh Mumbai, India New Delhi, India Pune, India Andra Pradesh, India

Exeter, UK Luton, UK Edinburgh, UK

ALFATECH ENGINEERING

ENGINEERING STUDIO AlfaTech’s Engineering Services is the apex supplier of high-quality, professional engineering services that help buildings thrive. We partner with clients to turn their visions into a tangible reality. As one of the leading MEP consultants in the Western U.S., AlfaTech strives to improve the life of hundreds of thousands of Americans every day through the buildings we design. Coining the expression “Innovation & Excellence,” AlfaTech is the apex supplier of high -quality, professional engineering services that help buildings thrive. AlfaTech partners with ambitious clients to turn visions into reality. To us, conscious design elements are indispensable in meeting the escalating expectations emerging within vibrant and diverse typologies. We believe the highest-efficiency buildings transpire from mirroring the sustainable features inherent to the world around us. Propelling cutting-edge solutions requires a thoughtful design that can interact with the physical environment. Elements like smart buildings, reduced reheat, and synergies before waste initiate perpetual savings. Eager to do our part, we pride ourselves on designing state-of-the-art facilities that reach unprecedented levels of integration. We think that sustainable design is more than just a phrase. It is a perspective. We are committed to rock-solid partnerships with our clients by delivering on our promise always to excel.

OCCUPANCY

DESIGN

CONSTRUCTION

END OF USE

SUSTAINABLITY

PROCESS ENGINEERING DESIGN

MECHANICAL ENGINEERING DESIGN

ELECTRICAL ENGINEERING DESIGN

ARCHITECTURAL LIGHTING DESIGN

TECHNOLOGY

COMMISSIONING / ENERGY SOLUTIONS

RETRO COMMISSIONING

LIFE OF A BUILDING

LABORATORIES Clinical QC BSL 1, 2 and 3 Flexible Labs

GENERAL BUILDING / CAMPUS SYSTEMS AND SPACES Site Electrical Distribution Backup Generation UPS HVAC Lighting and Lighting Controls BMS/EMS Central Plants Tank Farms and Utility Yards

PROCESS AND BUILDING UTILITY SYSTEMS WFI CIP and SIP Clean Steam Process Chilled Water RO/DI CDA Specialty Gases Lab Gases Solvent Systems Central Plants PLANT AND CLEAN AIR SYSTEMS Scrubbers Clean Rooms Explosion Relief HEPA Filtration Room Pressure Profiles and Cascade Exhaust Hoods and Dust Collection

PERMITTING AND REGULATORY COMPLIANCE FDA Inspection Readiness Support Air Permitting Support Code Analysis and Building Code Occupancy Issues Building Permit Administration and Support

cGMP COMPLIANT MANUFACTURING

FACILITIES Pilot Plants Clean Rooms Commercial Manufacturing Process Batching and Campaigning Areas Blending and Mixing Rooms Fill and Finish Wash Room Packaging and Labeling Isolation Technology Containment Facilities Gowning Rooms Production Equipment Specification Production Equipment Utility Hookup Warehouse and Material Handling

WASTE WATER AND HAZARDOUS WASTE TREATMENT Incineration

Truck Docks Warehouse Data Centers Corporate Office

Solids Removal Systems Waste Treatment Process Design Recycling Systems Heavy Metals Removal and Neutralization Reverse Osmosis and Ultra Filtration Biohazard Treatment and Detoxification

Electrical Distribution (480V to Low Voltage Systems) Technology Systems (Communication, AV, Security, WIFI)

ALFATECH PROJECT EXPERIENCE

Solutions for Life Science Facilities AlfaTech offers a full range of professional engineering services from concept creation to commissioning and validation, including feasibility studies, condition assessments, planning, design, program management and construction period services. Our experienced professionals are experts in cGMP and GLP compliance and understand the difficult decisions Life Science facility owners make every day when choosing between economy and function. Our team has the experience and capabilities to address projects throughout our clients’ facilities from labs to manufacturing or corporate office and campus infrastructure. We have the capacity, experience and business structure that allows us to support a wide range of projects from the small consulting scope to ground-up campus projects.

This combination of resources and skills provides a strong value proposition, predicated on innovative solutions and disciplined cost, quality and schedule management.

Our Services Process Engineering Lab Planning and Design Master Planning Mechanical Engineering Electrical Engineering Structural Engineering Architectural Lighting LV, AV and Security Design Facility Condition Assessment

Site Selection Sustainability FDA and EU Compliance Consulting Strategic Partner Services Architectural Planning and Design Structural Engineering Process Controls Validation Site Civil Engineering

Terasaki Research Group

West Los Angeles, CA

Tenant Improvement

TYPE:

AlfaTech is providing engineering design services for this project requiring an extensive renovation/transformation of an existing veterinary facility to create a new Vivarium suite within an animal research facility. The project included autoclave cage vivarium cage washers, bio-safety cabinets, procedure rooms, animal handling areas, Rheometer. The facility was designed in accordance with the AAALAC. guidelines. The existing electrical generator and vacuum systems within the veterinary clinic were repurposed and modified as necessary to suit. New HVAC equipment was added to isolate specific areas of the building and increase air change rates within the space. The existing surgery rooms were renovated to procedure rooms. The existing labs were renovated and re-purposed to match the programmatic requirements of the new tenant.

ALFATECH EXPERIENCE

AbbVie (Abbott Biotherapeutics)

Redwood City, CA

TYPE: SIZE:

New Construction, Tenant Improvement 400,000 SF

AlfaTech was selected as a turnkey firm to design and build Abbott's 400,000 SF new headquarters campus. The facility now houses an Abbott spinoff company called AbbVie. This project includes a 4,000 SF raised floor data center, tenant improvement of offices, along with laboratory facilities, and vivarium (animal care facility). A pilot plant (cell culture and purification) was built on the first floor along with new laboratory facilities, offices, and service yard. AlfaTech was fully responsibly for programming, design and construction of this state-of-the-art campus for which the budget and schedule was guaranteed as a part of our highly successful single-source project delivery method.

ALFATECH EXPERIENCE

Longfellow Real Estate Partners

San Francisco, CA

TYPE: SIZE:

Due Diligence, High-Rise 750,000 SF

The firm provided pre-acquisition due diligence for this 12-story, Class A 750,000 SF building at 1800 Owens which to determine the MEP scope of work to return the building to Life Science lab use.

ALFATECH EXPERIENCE

Longfellow Real Estate Partners

San Mateo, CA

TYPE: SIZE:

Due Diligence, High-Rise 240,000 SF

AlfaTech provided initial pre-acquisition due diligence for two buildings, 120,000 SF each, in San Mateo to determine the MEP scope of work to return the building to Life Science lab use.

AlfaTech is also providing the MEP design-build engineering services for conversion of the office buildings to Life Science lab use.

ALFATECH EXPERIENCE

SC Johnson Lifestyle Brands

San Francisco, CA

TYPE: SIZE:

Tenant Improvement 45,030 SF

AlfaTech provided the mechanical, electrical, plumbing and fire production engineering design for the tenant improvements to the 4th floor (45,030 SF) at 631 Howard. Programing included conversion from office space to life science lab space including a new formulation lab, packaging lab, and fragrance lab as well as plumbing for an Objet WaterJet and anchoring for 3D printers and other equipment. AlfaTech also provided Value Engineering recommendations for the project.

ALFATECH EXPERIENCE

Alza

Various Bay Area Sites

TYPE: SIZE:

New Construction, Tenant Improvement 1,000,000+ SF

AlfaTech and AlfaTech team members have provided design services for various Bay Area sites listed above.

Projects: Vacaville cGMP Facilities: • Original Manufacturing Building • Aqueous Tablet Coater • Fluid Bed Dryer • High Shear Granulation • Pharmaceutical Processing Area • Tablet Coating Process • Methylene Chloride Distribution

Mountain View Facilities: • Buildings M2 & M3 Biocenter • M1 Pilot Plant & Research Center

Palo Alto Facility: • Buildings M8 & M9 • Underground Tanks

ALFATECH EXPERIENCE

Genentech

South San Francisco, CA

TYPE: SIZE:

New Construction, Design-Build 100,000 SF

AlfaTech provided a new $1.1 million, 2-story facility for animal research labs and support areas. The mechanical design features double-duct, double-fan, constant volume mixing boxes with HEPA filtration. In addition, the firm provided full facility design services for Genentech’s Vacaville campus under a Master Services Agreement. This work encompasses office space, laboratory and cGMP manufacturing.

ALFATECH EXPERIENCE

Genentech*

South San Francisco, CA

TYPE:

Tenant Improvement

Small Portfolio Program ($10 mm and less construction value). Supported Genentech’s Small Project Portfolio program for the pharmaceutical research and manufacturing company’s South San Francisco Campus. Provided Architecture and Engineering planning, design and construction support for a wide variety of facility projects including research labs, GMP cold room upgrades, building condition assessment and upgrades, waste stream compliance and utility systems. Utility systems include electrical infrastructure, steam, compressed air, exhaust, fire suppression, domestic water, sanitary sewer, chilled water and plant gases.

ALFATECH EXPERIENCE

* Completed by AlfaTech principal during previous employment

Buck Institute Stem Cell Research Lab

Novato, CA

TYPE: SIZE:

Tenant Improvement 60,000 SF

AlfaTech provided project management, as well as mechanical and electrical engineering services for this project. Systems include the addition of a ground coupled geothermal system, which provides heating and cooling to the new addition and the existing 60,000 SF lab facility. Geothermal ground water at 61 degrees will be used to condition lab fume hood make up air, freeing up 300 tons of cooling from the existing central plant. The additional chilled water tonnage will be used for the new addition. The new geothermal system will provide all cooling & heating for the existing & new 60,000 SF lab building, and “no additional tonnage” will be required for the existing central plant. The geothermal system will also save 7,500.000 gallons of water a year from being evaporated via the existing (now decommissioned) cooling towers.

ALFATECH EXPERIENCE

Jazz Pharmaceuticals

Palo Alto, CA

TYPE: SIZE:

Tenant Improvement 98,000 SF

AlfaTech provided the mechanical, plumbing, fire protection and electrical engineering design for this project which consisted of tenant improvements of this two-story R&D building in Stanford Research Park. Programming featured multiple breakrooms, private and open offices, conference rooms, IDF/MDF rooms and a high-end multitenant lobby. Additionally, project includes a 2,000 SF multi-purpose room with a motorized skyfold partition and high-tech video array wall.

Completed: February 2019

ALFATECH EXPERIENCE

Nektar Pharmaceuticals

San Carlos, CA

Type: Size:

Tenant Improvement 4,000 SF

AlfaTech provided design services for the consolidation of the central data center, which will occupy approximately 4,000 SF in a currently unoccupied space for Building 3. The data center was designed to provide higher availability and growth capacity for current demand and future growth including 80kW APC, UPS frame with initial 40kW of UPS power, (2) 15-ton chilled-water system CRAC units, (21) seismic isolation base and structured cabling system.

Technology design included structured cabling for the data center, data network implementation, coordination of Telco facilities, security system design for card access and video surveillance, and PA/paging system.

ALFATECH EXPERIENCE

Gilead Sciences

Foster City, CA

TYPE: SIZE:

Tenant Improvement 500,000 SF

AlfaTech provided MEP and telecommunications design for Gilead’s campus consisting of 16 buildings including administrative and private offices, pharmaceutical development processing suites, pilot plants and cGMP therapeutic manufacturing / production areas. The firm also provided MEP engineering design services for Gilead’s 35,000 SF pilot plant on the Foster City campus as part of a previous project.

New Systems include: • Process Vacuum System • Nitrogen System • Process Compressed Air System • Cooling System • Dust Collection System

• Emergency Power System • Distribution System • Class II Hazardous Locations (Granulation and Drying, Milling and Blending, Tablet Coating, Tablet Compression, Weigh Room)

• Air Shower System • USP Water System • RO/DI Water System • Domestic Water System • N2 Gas System • Process Waste System • Building Service System

• Exhaust System • System Controls

ALFATECH EXPERIENCE

BioMarin Pharmaceutical

Novato, CA

TYPE: SIZE:

Tenant Improvement 20,000 SF

AlfaTech’s services included management oversight of facilities operations for the manufacturing plant during facility validation. Scope included management of standard operating procedures, spare parts, training of new systems, turnover of systems and facility from contractor to BioMarin and plant engineering services.

ALFATECH EXPERIENCE

The Jackson Laboratory West

West Sacramento, CA

TYPE: SIZE:

Tenant Improvement 91,000 SF

AlfaTech provided MEP design services for interior improvements to an existing tilt-up concrete warehouse, as well as an expansion into an existing facility. The new use of this space includes West Coast regional offices, animal vivarium, wash/sterilization facilities, various research laboratories, animal shipping/staging/support spaces, mechanical yard, and parking.

ALFATECH EXPERIENCE

Janssen Pharmaceuticals*

Vacaville, CA

TYPE:

Tenant Improvement

Janssen Pharmaceuticals operates a manufacturing site which was originally constructed in 1985. The HVAC design strategy originally employed consisted of installation of a dedicated HVAC systems for each separate space including each manufacturing suite, clean corridors, QC labs, washrooms, warehousing and administrative spaces. Between 2012 and 2019, Janssen embarked on a multi-year program to replace aging equipment. The effort included developing multiple options for consolidation of systems for cost and space efficiency while ensuring proper air distribution and balancing across the highly diverse environments in the building. Protecting again cross contamination and release of toxic chemicals was a top priority. The program also included goals for energy efficiency achieved by specifying highly efficient units, reviewing and revising required air changes and improving system monitoring and control.

ALFATECH EXPERIENCE

* Completed by AlfaTech principal during previous employment

Amgen, Buildings 31 And 42

Thousand Oaks, CA

TYPE: SIZE:

Tenant Improvement Building 31, 10,000 SF; Building 42, 15,000 SF

Amgen is a global biotechnology company that discovers, develops, manufactures and markets cost- effective human therapeutics based on advances in cellular and molecular biology. A large-scale dispensing suite was added to Building 31 and Building 42 was a new cGMP raw material receiving facility. On Building 31, AlfaTech provided mechanical, electrical, plumbing, support utility design, specifications, and specialized equipment sourcing for construction of cGMP raw material dispensing suites within an existing warehouse and distribution facility. Building 42 was programmed and designed for cGMP raw material receiving and support for Building 23, a clinical trial manufacturing facility. Process engineering design included liquid caustic solution receiving, storage and transfer systems, and fresh and waste glycerol streams storage and transfer systems.

ALFATECH EXPERIENCE

Genencor

Palo Alto, CA

TYPE: SIZE:

Tenant Improvement 77,500 SF

This International Technology Center facility combines basic research, pilot plant development, and robotics under one roof. This cGMP project required complete equipment layout, installation design for a pre- manufactured fermentation skid, tank design, and design of three automated 1,500-liter recovery vessels.

ALFATECH EXPERIENCE

Beyond Meat Headquarters

El Segundo, CA

TYPE: SIZE:

Tenant Improvement 250,000 SF

AlfaTech is providing mechanical, electrical, plumbing, fire protection and process piping engineering design services for the relocation to the new headquarters for Beyond Meat into a 2-story building. Project includes complete demolition of the interior and will consist of a 143,000 SF R&D, Lab Space, Test Kitchens and Refrigerated Storage and 107,000 SF office space in a phased construction. Project included the design of the “house” high pressure steam system (100 PSIG), including steam boilers, a deaerator/boiler feedwater system, a blowdown tank, a flash tank, chemical treatment, steam system controls, a steam distribution system (including expansion joints), steam trapping, condensate distribution, condensate pumps, condensate coolers, etc. Also included was a “clean - steam” generator and a clean -steam distribution system.

ALFATECH EXPERIENCE

*Confidential Client, Textured Vegetable & Fiber Spin Pilot Labs

Redwood City, CA

TYPE:

Tenant Improvement

This confidential client is on a mission to be the future of sustainable food by giving people options to reduce their carbon footprint by consuming their plant-based meat products. This project retrofitted an existing building into labs for textured vegetable protein extrusion processing line and fiber spin aqueous based process line. Multiple process equipment vendors were evaluated for viability of the clients changing processing needs throughout the duration of the process. Provided MEP design for the cGMP equivalent labs designed to food grade standards. New systems included food grade air handling, solvent bunker, dust collection system, food grade steam, RO water, process cooling water, compressed air, CIP/COP, wastewater treatment, building service system and lighting.

ALFATECH EXPERIENCE

* Completed by AlfaTech principal during previous employment

Niagara Bottling, LLC

Diamond Bar, CA

TYPE: SIZE:

Tenant Improvements 382,000 SF

Niagara Bottling, LLC is a family-owned manufacturer of bottled water and soft drinks based in Ontario, California. They produce private label bottled water for a number of companies including Wal-Mart and Costco. As of 2017 Niagara was the largest supplier of private label bottled water in America. Niagara looked towards creating a unique experience for their staff at their new Corporate Headquarters Campus. The scope of work comprised of a core and shell renovation and simultaneous TI of Bldg. 1 (182,000SF), R&D and QA Lab in Bldg. 2 (20,000 SF), site improvements (80,000 SF), 500kW Campus E-Power System and lighting, power and EV charging renovations to a (176,000 SF) parking structure. The Lab comprised of Analytical Rooms, Micro Rooms, Q/A Lab, Sample Storage Rooms, Cold Storage Rooms, R&D Lab and office space. The main office building included a full- service staff cafeteria with waste composting system, Executive Offices, Private offices, Tasting Lounge/Kitchen, Conference rooms, Open Office Space, 3 Story main reception lobby, flex spaces, games rooms, (6) IDF rooms and a Main Server/MDF room.

ALFATECH EXPERIENCE

Confidential Life Sciences Campus Repositioning

Los Angeles, CA

TYPE: SIZE:

Tenant Improvement 180,000 SF

Scope was to convert 4 office buildings totaling over 180,000 SF into life science incubator labs, office space and cGMP space.

ALFATECH EXPERIENCE

Soka University Of America

Aliso Viejo, CA

TYPE: SIZE:

New Construction 200,000 SF

The firm provided mechanical, electrical, and plumbing engineering design services for this university campus expansion project for Soka University which consists of two buildings.

The 4-story, 100,000 SF STEM building houses teaching, science and research laboratories, classrooms, offices, a large auditorium, collaboration areas, meeting rooms, open study areas. The building’s instructional lab modules allow for interactive teaching and hands-on learning in this open, flexible, interactive and sustainable building.

The Resident Housing is 4-stories and approximately 65,000 SF comprised of approximately 75 to 80 rooms and a rooftop patio.

Both proposed projects were designed to accommodate a LEED Gold Building Certification, and an exterior architectural design pallet that will respect the current design features, landscaping and cultural aspects of the campus.

ALFATECH EXPERIENCE

Stanford University Clark Center

Palo Alto, CA

TYPE: SIZE:

Peer Review, New Construction 200,000 SF

This award-winning 200,000 SF project is a multi-story building on the Stanford University campus dedicated to biotechnology research and development. It is a state-of-the-art facility designed to bring together researchers of different disciplines in order to foster new ideas as opposed to the process of traditional research facilities.

The firm was responsible for the design of the HVAC, fume exhaust, building automation, and peer review of the plumbing/process piping systems.

ALFATECH EXPERIENCE

UCLA Terasaki Life Sciences Building*

Los Angeles, CA

TYPE: SIZE: ACCREDITATION:

New Building 175,000 SF

LEED Silver

Terasaki Life Sciences Building features two wings with laboratories, offices, scholarly activity space, and building support spaces on five floors plus a basement vivarium. The 175,000 SF structure is supported by a cast-in-place concrete frame with flat-slab floor decks. This building, is the new home of the Biological Sciences Department. A stated goal of the UCLA Terasaki Life Sciences Building Detailed Project Program is to “provide flexible facilities that anticipate changing future needs.” To help meet thi s goal, the building was designed with large, open laboratory spaces to allow multiple scientists to work in shared laboratories, uninterrupted by doors or walls. Each rectangular wing houses an efficient pattern of laboratory, support and office space of five above ground levels. The building’s concrete frame eliminates 10 ft in height, as compared to the common structural steel alternative and provides inherent vibration control.

The vivarium on the lower level includes holding rooms for rodents, birds, fish and other small animal species.

ALFATECH EXPERIENCE

* Completed by AlfaTech principal during previous employment

Confidential Client, Covid19 Testing Lab (BSL2)

Sunnyvale, CA

TYPE:

Tenant Improvement

Major e-commerce client approached AT in Mid-April to aggressively install onsite virus testing labs. Parallel development of mobile modular labs and TI / brick and mortar labs for COVID19 testing. Satellite locations throughout the US are being established for quick testing turnaround following Federal CDC guidelines for virus testing labs which are BSL-2 biosafety level. Established laboratory operations and PCR processes to help control contamination. Develop a (1) line (1,000 samples), (2) line (7,500 samples) and (4) line (estimated 20,000 samples daily). The mechanical team provided 15 ACH 100% exhaust with the DOAS and used cascade pressurization with the testing part of the lab being the most negative with pre-testing room second most negative, while pressurizing all adjoining spaces to eliminate cross contamination. IAQ Photocatalytic Virus Filters and final HEPAS on the supply air were also provided. The electrical research and coordination with lab owner in development of lab tool matrix, In depth analysis of existing electrical service, metering of existing loads, in order to determine the best power source for new lab and its associated HVAC equipment. Also reviewed the backup power requirements and sizing UPS and generator requirements. Plumbing provided required eye wash system and fixtures with auto faucets. The Team worked closely with Owner, Contractor, Vendors & City Planning to achieve TCO for pilot lab in 14 days (design and construction).

ALFATECH EXPERIENCE

*Dupont/Genencor, Lab Expansion

Palo Alto, CA

TYPE: SIZE:

Tenant Improvement 20,000 SF

This lab expansion project was an expansion of the food-grade fermentation, large scale recovery, small scale recovery, and granulation lab suites/processes. The 20,000 SF expansion included two new 2,000L fermentation vessels and associate holding tanks, four new 1,500L recovery vessels, an entirely new 14L small scale recovery suite with Millipore, Buchner, and Microfiltration processing, and spray dryer process addition to Granulation Suite/Process. Provided complete mechanical, electrical, plumbing, and process piping design including coordination with process equipment vendors. Collaboration with scientists to develop custom Millipore Bench and Buchner walk-in hoods with special consideration for enzyme aerosol mitigation. Process and utility piping design to support the new process vessels and equipment including Steam & Condensate, Compressed Dry Air, Hot and Cold Glycol, Heating Hot Water, DI Water, Industrial Cold & Hot Water, Process Vacuum, and Contained Drains.

Collagen Aesthetics INC.

Fremont, CA

TYPE: SIZE:

Tenant Improvement 12,000 SF

Collagen Aesthetics Inc. develops, manufactures, and markets on a worldwide basis high quality biocompatible products for the treatment of defective, diseased, traumatized or aging human tissues. This project modified existing Class 100 – 10,000 spaces for laminar flow filling suites for new product manufacturing. The firm maintains Collagen’s library of as -built drawings to support ISO 9001 certification.

Facilities: • Bulk Processing Area Addition • Office Space Tenant Improvements • Warehouse and Office Space

ALFATECH EXPERIENCE

Xoma Therapeutics

Berkeley, CA

TYPE: SIZE:

Tenant Improvement 8,000 SF & 10,000 SF

For the Pilot Plant, the project includes conversion of the X-5 pilot plant to a combination of manufacturing and research. Modifications were made to the existing facility, bringing it to current ADA standards, and generally “state -of-the- art” status. For the cGMP warehouse facility, the firm provided full design services which entailed the renovation of an existing facility along with validation support and construction management. The warehouse concept entailed the renovation of an existing facility along with validation support.

Xoma Therapeutics

Berkeley, CA

TYPE: SIZE:

New Construction 5,000 SF & 12,000 SF

For the 5,000 SF Fermentation Suite, AlfaTech provided full design and construction management for its GMP new 2,000-liter fermentation suite along with validation support. Design for the 12,000 SF Suite provided a new cGMP fermentation suite consisting of 50 L, 130L, 500L, 2750L, and 12,000L fermenters. These were fully automated with CIP and SIP capability. In addition, a number of media preparation and purification vessels were specified.

ALFATECH EXPERIENCE

JRH Biosciences

Woodland, CA

TYPE: SIZE:

Tenant Improvement 30,000 SF

This facility produces media for cell metabolism studies and growth kinetics. It is also used for the research, development and manufacture of proprietary client products.

Process piping included a WFI system with a high temperature (85 ° C) and ambient (25 ° C) loop and all necessary controls; a clean steam and plant system complete with boiler feed water pump system and blow down cooler; R.O. piping loop and system; process cooling water system with fluid cooler and chilled water heat exchanger; and process gases.

ORead

Palo Alto, CA

TYPE: SIZE:

New Construction Robotics Lab, 1,000 SF, Chemistry Lab, 10,000 SF

Oread is a contract provider of comprehensive contract drug development, clinical trial support, finished product manufacturing and packaging, and regulatory support for the pharmaceutical industry. AlfaTech provided full engineering services for a robotics dissolution laboratory and the installation of a new formulation chemistry facility with a cGMP WFI system (1,000-gallon storage capacity). Extensive fume hoods contain MRI lab system and sterilizer. AlfaTech worked closely with the client during the programming phase and to make sure that the robotics facility, which features a robotically-controlled vial- fill system, would be validatable. The firm also managed the preparation of mechanical, electrical, plumbing, and process designs to meet city permit deadlines.

Facilities: • Chemistry Lab • Robotics Lab • WFI/USP Water System

ALFATECH EXPERIENCE

Vivus

Lakewood, NJ

TYPE: SIZE:

Tenant Improvement 80,000 SF

AlfaTech acted as the owner’s principal engineer for design of a facility that expanded their capacity to formulate and produce a new drug and drug delivery system. The scope of work involved HVAC, process utilities, R.O./D.I. and hot USP water systems, production room layout, and general engineering support. AlfaTech also worked closely with the validating agency to provide a complete turnover package.

Baxter Healthcare

Hayward, CA

TYPE:

Tenant Improvement

This Hyland Division Laboratory renovation project involved a complete remodel and relocation of the biotechnology process rooms. Construction documents and validation for a cGMP upgrade of the existing facility were also required.

ALFATECH EXPERIENCE

*BioMarin Pharmaceutical

Novato, CA

TYPE:

Tenant Improvement

Engineering Design of HVAC, process systems and piping including process cooling water (PCW), clean in place (CIP) systems, deionized water (DI), water for injection (WFI), clean dry air (CDA) and plumbing for build out of shell space to new R&D laboratories.

*BioMarin Pharmaceutical

Novato, CA

TYPE:

Tenant Improvement

BioMarin executed a utility yard expansion to accommodate additional capacity for lab and manufacturing facilities. The project included specification and conceptual design for addition of a 400-ton chiller to an existing 1000-ton system and 7,000 lb steam boiler to an existing 125 psig plant steam system. The scope also included design of a new enclosed two-story plant utility yard structure with architectural finishes to match the existing building. Challenges included design of new distribution piping to connect new equipment to the existing chilled water and plant steam systems, accommodation of existing equipment including emergency generator and water treatment systems as well as the facility’s loading dock.

ALFATECH EXPERIENCE

* Completed by AlfaTech principal during previous employment

*BBraun Irvine, CA

TYPE:

Master Planning

Responsible for the Site Master Planning Options development and the Facility Planning, Evaluation of criteria and constraints, Developing Options for Steering committee selection.

*McGuff Pharmaceutical

Santa Anna, CA

TYPE: SIZE:

Master Planning 80,000 SF & 60,000 SF

Responsible for Master Planning, Options Development, Programming, and Conceptual Design for two separate facilities, 503a &503b. On a Greenfield 80,000 SF & 60,000 SF

ALFATECH EXPERIENCE

* Completed by AlfaTech principal during previous employment

SLAC National Accelerator Laboratory

Palo Alto, CA

TYPE:

Feasibility Study

AlfaTech provided a feasibility study for the FEH Hutches 4, 5 and 6 project to define alternate system solutions for the HVAC design. The project was in the final design phase using a single unit air handling system. The distribution system was going to occupy space that the owner wanted to reserve for future use. We provided a conceptual design study to evaluate how much space could be saved using a different system. The study included pros and cons of each system, sketches for cost estimating and peer review of existing design documents.

*Par, Fairbank OSD

Irvine, CA

TYPE: SIZE:

Master Planning 90,000 SF

Responsible for Master Planning, Options Development, Programming, and Conceptual Design of the facility. For an existing 90,000 SF OSD Facility that includes manufacturing, QC lab, lab support, warehousing and administrative functions

ALFATECH EXPERIENCE

* Completed by AlfaTech principal during previous employment

Bayer Healthcare

Berkeley, CA

Tenant Improvement 40,000 SF

TYPE: SIZE:

AlfaTech was selected to perform design construction management services for the replacement and upgrade of the B55 WFI system. The state-of-the-art replacement WFI system consisted of a single HWFI loop with multiple POU heat exchangers. WFI temperatures at the POUs were controlled using HMI panels. The firm scope of work included: interviews with the users to determine WFI consumption; production of complete WFI design-built and demo bid packages; procurement of owner- furnished components; selection of a design-built contractor; and management of the final design and construction effort.

*Bristol-Myers Squibb

Redwood City, CA

TYPE:

Tenant Improvement

This project consisted of replacement of an aging and inefficient chilled water system serving Autoclaves in the facility’s vivarium. A key project challenge included addressing a widely variable load. The chiller was specified with three compressors to allow efficient coverage of the loads.

ALFATECH EXPERIENCE

* Completed by AlfaTech principal during previous employment

*Novartis (Chiron)

Vacaville, CA

TYPE: SIZE:

Tenant Improvement 17,000 SF

Full Civil and MEP design services for a 17,000 SF two-story building expansion. The expansion included private offices, open office areas, meeting, conference and storage rooms, corridors, stairs, restrooms, elevator, QA/QC engineering document storage room, QC and raw materials laboratories and process equipment storage, in the following cGMP areas: weigh/dispense room, quarantined and released materials.

*Novartis (Chiron)

San Carlos, CA

TYPE:

Tenant Improvement

Engineering Design for multiple facility projects including: • Temperature Control for CSD-1 Dryer • Laboratory Humidification System Replacement • Site Energy Manager (Staff Augmentation) • Sitewide Electrical Power Study and Maintenance Plan • Niro-2 Exhaust Modifications (Design/Build Project Delivery)

ALFATECH EXPERIENCE

* Completed by AlfaTech principal during previous employment

*Novartis (Chiron)

Emeryville, CA

TYPE:

Tenant Improvement

Architecture and Engineering Design for multiple facility projects including: • Site Wide Energy Efficiency Study • Building 4 Lab Tenant Improvements • Robotics Lab Tenant Improvements • Building 4 Executive Conference Center • Building G&T Chilled Water System Upgrades Concept Design

Aradigm

Hayward, CA

TYPE:

Tenant Improvement 20,000 SF

Aradigm is engaged in the development of novel pulmonary drug delivery systems designed to enhance the delivery and effectiveness of a number of existing and development stage drugs and reduce the need for injectable drug therapy. Clinical trial Phase III quantities of three new products for inhalation therapy will be produced at the new full-scale cGMP clinical and manufacturing facility. AlfaTech also provided services at Aradigm’s 30,000 SF production facility.

The project has extensive clean rooms, including Class 100 laminar flow processing areas; a WFI generation and distribution system; and high purity gas distribution.

ALFATECH EXPERIENCE

* Completed by AlfaTech principal during previous employment

*Bayer Healthcare

Berkeley, CA

TYPE:

Tenant Improvement

The goal of this project was to improve occupant comfort and the energy profile of the nearly 100- year-old Building B14 which was being used by research team for critical future drug products. Project challenges included very limited capital available and architectural constraints of a building constructed before HVAC systems were invented such as low ceilings, and no interstitial space. The project team the Target Costing methodology to prioritize the design features in order to stay within budget as a result of early collaboration between the design team, the contractor, the site facility team and the end user. Project features included replacement of existing air handlers, replacement of windows to reduce heat gain and careful HVAC zoning within the space. The project required detailed implementation planning as the project was installed over several budget years.

*Bayer Healthcare

Berkeley, CA

TYPE:

Tenant Improvement

This project involved the relocation of Bayer’s BioAnalytics lab necessitated by the planned demolition of the aging building housing the original lab. The project included redesign of the lab layout to improve workflow and accommodate lab analytical equipment and sample storage freezers, design of gas utilities, wet utilities and waste, electrical power and lighting, cabinetry and architectural finishes.

ALFATECH EXPERIENCE

* Completed by AlfaTech principal during previous employment

*Janssen Pharmaceuticals

Vacaville, CA

TYPE:

Tenant Improvement

Numerous upgrade and expansion projects were executed throughout all aspects of the facility including labs, manufacturing process and HVAC systems and building utility upgrades, manufacturing clean room projects, site infrastructure and utilities and administrative tenant improvements. Projects included: • Multi-year plantwide HVAC system renovation and replacement to modernize the plant’s clean room HVAC systems and to meet cGMP requirements. • Process Dust Collection System collecting hazardous dust produced pharmaceutical product manufacturing. • Manufacturing Suite projects to accommodate new products and processes including suite workflow layout, utility system design (electrical, O2, AOF, N2, chilled water, clean steam, etc.), waste streams, Architectural improvements. • Regenerative Thermal Oxidizer • Manufacturing Equipment Safety Upgrades to meet J&J Corporate safety standards • Raw Materials Warehousing and Lab • 1MW Solar Farm Condition Assessment and Upgrades • Manufacturing Washrooms • QC Labs

• Code Studies • Data Center

ALFATECH EXPERIENCE

* Completed by AlfaTech principal during previous employment

ALFATECH PROJECT TEAM

Organization Chart

TPC

Gensler

Principal-in-Charge

Terry Stelter

Gerald ‘Jerry’ Hartford, Jr, PE, LEED AP, GPD Project Manager

Leanne Cossairt-Leung, PE, LEED AP BD+C Lead Process Piping

Gerald ‘Jerry’ Hartford, Jr, PE, LEED AP, GPD Lead Mechanical

Lead Electrical

Kristoffer Cercena, PE

The above Organization Chart and following key staff resumes identifies the key staff members, however additional staff will be included to provide design engineering support, modeling, design criteria editing and other critical functions.

Terry Stelter

Principal-in-Charge terry.stelter@atce.com Sr Principal

PROJECT EXPERIENCE

FIBROGEN, San Francisco, CA Project Manager for the mechanical, electrical, plumbing, process and fire protection Due Diligence assessment of all spaces in their current building. The building is a 234,249 SF six-story high-rise lab/office building with a café/kitchen on the 4th floor and basement levels of shared parking, as well as a vivarium. *BRISTOL-MEYERS SQUIBB, Redwood City, CA Principal in Charge for the design and installation of a chilled water system serving Autoclaves in the facility’s vivarium. LONGFELLOW REDWOOD SHORES AND PATC SPEC LAB, Redwood City, CA Principal-in-Charge for this project consisting of updates and fine-tuning of the MEP sections of the Bayshore and PATC Spec Lab Basis of Design document with details that further define system and equipment specifications for Mechanical, Electrical, and Plumbing systems used on the campuses. LONGFELLOW STANDARD BACKUP GENERATOR, Redwood City, CA Principal-in-Charge for this project consisting of a study to identify the optimum solution for generator size based on cost benefit and then prepare a standard design package. Future scope would include site adaptation of the standard package to accommodate each building as generation capability is installed, as well as plan check and CA services for specific buildings. LONGFELLOW STANDBY POWER DESIGN, Redwood City, CA Principal-in-Charge for this project consisting of includes preparing standard design drawings that would be updated to install at a specific building in the future as buildings are identified (electrical and foundation pad). Work also included a design package for plan check and to provide CA services for this first installation. LONGFELLOW REAL ESTATE PARTNERS, San Francisco, CA Project Manager for this Due Diligence project of property including a large 760,000 SF office/lab building consisting of four buildings originally built for lab use and then converted to office by Dropbox. The goal was to determine the MEP scope of work necessary to return the building to Life Science lab use. LONGFELLOW REAL ESTATE PARTNERS, San Francisco Bay Area, CA Principal-in-Charge for a pre-acquisition due diligence for 1M SF of Office Buildings for conversion to Life Sciences. Scope included evaluation of existing conditions, development of MEP concepts for conversion of offices to lab/office split with various use ratios on a fast-track basis.

EDUCATION

BS, Civil Engineering, University of California, Davis, CA

AFFILIATIONS International Society of Pharmaceutical Engineers (ISPE), NC Chapter Structural Engineering Association of Northern California (SEAONC)

Terry Stelter is the Senior Principal in charge of the AlfaTech Consulting Engineer’s Life Sciences business unit. He has extensive experience with multi-disciplined teams for many high-profile clients in the Life Sciences industry. Terry's Life Science experience includes projects in R&D laboratories, pharmaceutical manufacturing, commercial buildings for life sciences clients, and campus infrastructure. He is well versed in cGMP requirements and design and construction standards required for FDA compliance. He has extensive experience in the pharmaceutical, biotech and medical device industries, with notable clients such as Genentech, Bayer, Johnson and Johnson, and Novartis.

Facilities Designed: •

Systems Designed: • HVAC • Steam • Compressed air • Exhaust • Fire suppression • Domestic water • Sanitary sewer • Chilled water • Plant gases • Waste streams

Process cooling water (PCW)

• • • •

R&D Facilities

GMP Cold Room

QC Labs

Raw materials warehouse/lab

ALFATECH PROJECT TEAM

*denotes work performed with previous firm.

EXPERIENCE CONTINUTED …

8100 JARVIS LIFE SCIENCE LAB WARM-UP, Newark, CA Principal-in-Charge for this project consisting of converting two 49,000 SF office buildings for Life Sciences use. Work consists of the MEP Basis of Design and detailed design phases. BIO-RAD RESIN CAPACITY EXPANSION PROJECT, Richmond, CA AlfaTech prepared the Basis of design for Bio- Rad’s capacity expansion project. The scope included development of mass balances and determination of production bottlenecks to identify new equipment required to accommodate projected production targets. The team developed the basis for process, mechanical, electrical, controls and structural design for renovation of the existing Richmond plant. 10x GENOMICS, Pleasanton, CA Principal-in-Charge for this project consisting of design and construction of two ISO 6 clean rooms with localized ISO 5 environments. The facility manufactures diagnostic equipment including semiconductor equipment. The facility includes DI water, chilled water, solvent system, lab gases, gas monitoring and hazardous material storage and hazardous waste collection. AT provided all architectural design for the clean rooms, gowning rooms and utility rooms as well as all process piping. We provided peer review of HVAC, electrical and structural design. *JANSSEN PHARMACEUTICALS, Vacaville, CA Principal in Charge for numerous facilities upgrade and expansion projects since 1996. Projects were executed throughout all aspects of the facility including labs, manufacturing process and HVAC systems and building utility upgrades, manufacturing clean room projects, site infrastructure and utilities and administrative tenant improvements. Projects included: • Multi-year plantwide HVAC system renovation and replacement to modernize the plant’s clean room HVAC systems and to meet cGMP requirements. • Process Dust Collection System collecting hazardous dust produced pharmaceutical product manufacturing. • Manufacturing Suite projects to accommodate new products and processes including suite workflow layout, utility system design (electrical, O2, AOF, N2, chilled water, clean steam, etc.), waste streams, Architectural improvements. • Regenerative Thermal Oxidizer • Manufacturing Equipment Safety Upgrades to meet J&J Corporate safety standards • Raw Materials Warehousing and Lab • 1MW Solar Farm Condition Assessment and Upgrades • Manufacturing Washrooms • QC Labs • Code Studies

*BAYER HEALTHCARE, Various Projects, Berkeley, CA Project Executive for several projects at Bayer’s Berkeley campus. Projects included the upgrade of the HVAC system for the nearly 100-year-old B14. Performed the project using Target Costing methodology. In addition, he managed work to relocate the plant’s BioAnalytics lab including redesign of the lab layout, provision of all utilities and architectural design including cabinetry and finishes. ST. *GENENTECH, South San Francisco, CA Principal in Charge supporting Genentech’s Small Project Portfolio program for the pharmaceutical research and manufacturing company’s South San Francisco Campus. Provided Architecture and Engineering planning, design and construction support for a wide variety of facility projects including Research labs, GMP Cold Room upgrades, Building condition assessment and upgrades, waste stream compliance and utility systems. Utility systems include electrical infrastructure, steam, compressed air, exhaust, fire suppression, domestic water, sanitary sewer, chilled water and plant gases. *CONFIDENTIAL CLIENT, Novato, CA Project Executive for a utility yard expansion for lab and manufacturing facilities. The project included specification and design for addition of a 400-ton chiller to an existing 1000-ton system and 7,000 lb steam boiler to an existing 125 psig plant steam system. The scope also included design of a new enclosed two-story plant utility yard structure with architectural finishes to match the existing building. Challenges included design of new distribution piping to connect new equipment to the existing chilled water and plant steam systems, accommodation of existing equipment including emergency generator and water treatment systems as well as the facility’s loading dock.

*MYLAN SPECIALTY/DEY LABS, Napa, CA – Multiple Projects Project Manager/Principal in Charge for a series of projects including:

• Site Server Room HVAC Upgrades • Building 1 Main Lobby and Reception

*Eli Lilly, Indiana – Multiple Projects Principal in Charge for a series of facility and process utility upgrades including chilled water and process water systems.

STELTER, TERRY

*denotes work performed with previous firm.